The Immunological Basis of Inflammatory Bowel Disease

被引：115

作者：

Silva, Francesca A. R. ^{[1
]}

Rodrigues, Bruno L. ^{[1
]}

Ayrizono, Maria de Lourdes S. ^{[1
]}

Leal, Raquel F. ^{[1
]}

机构：

[1] Univ Estadual Campinas, UNICAMP, Inflammatory Bowel Dis Res Lab, Med Sch,Gastroctr,Surg Dept, Campinas, SP, Brazil

来源：

GASTROENTEROLOGY RESEARCH AND PRACTICE | 2016年 / 2016卷

关键词：

REGULATORY T-CELLS; NF-KAPPA-B; INTESTINAL MONONUCLEAR-CELLS; TUMOR-NECROSIS-FACTOR; ULCERATIVE-COLITIS; CROHNS-DISEASE; LAMINA PROPRIA; INNATE; PATHOGENESIS; GUT;

D O I：

10.1155/2016/2097274

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel diseases (IBDs) are chronic ailments, Crohn's disease and ulcerative colitis being the most important. These diseases present an inflammatory profile and they differ according to pathophysiology, the affected area in the gastrointestinal tract, and the depth of the inflammation in the intestinal wall. The immune characteristics of IBD arise from abnormal responses of the innate and adaptive immune system. The number of Th17 cells increases in the peripheral blood of IBD patients, while Treg cells decrease, suggesting that the Th17/Treg proportion plays an important role in the development and maintenance of inflammation. The purpose of this review was to determine the current state of knowledge on the immunological basis of IBD. Many studies have shown the need for further explanation of the development and maintenance of the inflammatory process.

引用

页数：11

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