Antimycobacterial activity of new ortho-, meta- and para-toluidine derivatives

被引：17

作者：

Biava, M

Fioravanti, R

Porretta, GC

Sleiter, G

Deidda, D

Lampis, G

Pompei, R

机构：

[1] Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

[3] Univ Roma La Sapienza, CNR, Ctr Studio Meccanismi Reaz, I-00185 Rome, Italy

[4] Univ Cagliari, Fac Sci Matemat Fis Nat, Cattedra Microbiol Applicata, I-09124 Cagliari, Italy

来源：

FARMACO | 1999年 / 54卷 / 11-12期

关键词：

antimycobacterial activity; ortho- meta- and para-toluidines;

D O I：

10.1016/S0014-827X(99)00084-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Novel toluidine derivatives are described. Some of them showed an interesting in vitro activity against Mycobacterium tuberculosis, M. smegmatis, M. marinum, M. gordonae, and M. avium. Some of them were more active than Streptomycin and Isoniazid, which were used as controls, against M. avium and M. gordonae. In particular, we confirm the good activity of biphenyl derivatives. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：721 / 727

页数：7

共 17 条

[1] N-[4-(1,1′-biphenyl)methyl]-4-(4-thiomorpholinylmethyl)benzenamines as non-oxazolidinone analogues of antimycobacterial U-100480. [J].