Sequence analysis of the non-structural 3A and 3C protein-coding regions of foot-and-mouth disease virus serotype Asia1 field isolates from an endemic country

被引：13

作者：

Biswas, S. ^{[1
]}

Sanyal, A. ^{[1
]}

Hemadri, D. ^{[1
]}

Tosh, C. ^{[1
]}

Mohapatra, J. K. ^{[1
]}

Kumar, R. Manoj ^{[1
]}

Bandyopadhyay, S. K. ^{[1
]}

机构：

[1] Project Directorate Foot & Mouth Dis, Naini Tal 263138, Uttaranchal, India

来源：

VETERINARY MICROBIOLOGY | 2006年 / 116卷 / 1-3期

关键词：

FMDV; serotype Asia1; 3A and 3C; phylogeny; sequence analysis;

D O I：

10.1016/j.vetmic.2006.03.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A total of 18 foot-and-mouth disease virus (FMDV) serotype Asial field isolates belonging to two different lineages (including the divergent group) as delineated earlier in VP1-based phylogeny were sequenced in the non-structural 3A and 3C protein-coding regions. The phylogenetic trees representing the regions coding for the non-structural proteins were very similar to that of the structural VP1 protein-coding region. Phylogenetic comparison at 3C region revealed clustering of Asial viruses with the isolates of serotypes O, A and C in the previously identified clade. Comparison of amino acid sequences identified lineage-specific signature residues in both the non-structural proteins. Overall analysis of the amino acid substitutions revealed that the 3A coding region was more prone to amino acid alterations than 3C region. (c) 2006 Elsevier B.V.. All rights reserved.

引用

页码：187 / 193

页数：7

共 23 条

[1] The pathogenesis and diagnosis of foot-and-mouth disease [J].

Alexandersen, S ;

Zhang, Z ;

Donaldson, AI ;

Garland, AJM .

JOURNAL OF COMPARATIVE PATHOLOGY, 2003, 129 (01) :1-36

[2] Genetic determinants of altered virulence of taiwanese foot-and-mouth disease virus [J].

Beard, CW ;

Mason, PW .

JOURNAL OF VIROLOGY, 2000, 74 (02) :987-991

[3] Genetic comparison of large fragment of the 5′ untranslated region among foot-and-mouth disease viruses with special reference to serotype Asia1 [J].

Biswas, S ;

Sanyal, A ;

Hemadri, D ;

Tosh, C ;

Mohapatra, JK ;

Kumar, RM ;

Bandyopadhyay, SK .

ARCHIVES OF VIROLOGY, 2005, 150 (11) :2217-2239

[4]

DOMINGO E, 1992, CURR TOP MICROBIOL, V176, P33

[5] NUCLEOTIDE-SEQUENCE AND GENOME ORGANIZATION OF FOOT-AND-MOUTH-DISEASE VIRUS [J].

FORSS, S ;

STREBEL, K ;

BECK, E ;

SCHALLER, H .

NUCLEIC ACIDS RESEARCH, 1984, 12 (16) :6587-6601

[6]

GEORGE M, 2000, THESIS DEEMED U INDI

[7] IDENTIFICATION OF THE ACTIVE-SITE RESIDUES OF THE 3C PROTEINASE OF FOOT-AND-MOUTH-DISEASE VIRUS [J].

GRUBMAN, MJ ;

ZELLNER, M ;

BABLANIAN, G ;

MASON, PW ;

PICCONE, ME .

VIROLOGY, 1995, 213 (02) :581-589

[8]

Holland JJ, 1982, CURR TOP MICROBIOL I, V176, P1

[9]

KNOLWES NJ, 1995, POLYM CHAIN REACTION, P45

[10] Emergence in Asia of foot-and-mouth disease viruses with altered host range: Characterization of alterations in the 3A protein [J].

Knowles, NJ ;

Davies, PR ;

Henry, T ;

O'Donnell, V ;

Pacheco, JM ;

Mason, PW .

JOURNAL OF VIROLOGY, 2001, 75 (03) :1551-1556

← 1 2 3 →