In Brief: Notch signalling in health and disease

被引：37

作者：

Aster, Jon C. ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

来源：

JOURNAL OF PATHOLOGY | 2014年 / 232卷 / 01期

关键词：

Notch signalling; developmental disorders; cancer; viral infections;

D O I：

10.1002/path.4291

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Notch pathway controls many aspects of development and is mutated in various human cancers. Remarkably, Notch function changes during the development of cellular hierarchies and can be either oncogenic or tumour-suppressive, depending on cellular context. Notch dysregulation is also important in cardiovascular disease and disorders of immunity. This mini-review outlines key features of the Notch signalling pathway and emerging data linking it to human diseases. Copyright (c) 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：1 / 3

页数：3

共 4 条

[1] Targeting the Notch Pathway: Twists and Turns on the Road to Rational Therapeutics [J].

Aster, Jon C. ;

Blacklow, Stephen C. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (19) :2418-2420

[2] Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry [J].

Kluk, Michael J. ;

Ashworth, Todd ;

Wang, Hongfang ;

Knoechel, Birgit ;

Mason, Emily F. ;

Morgan, Elizabeth A. ;

Dorfman, David ;

Pinkus, Geraldine ;

Weigert, Oliver ;

Hornick, Jason L. ;

Chirieac, Lucian R. ;

Hirsch, Michelle ;

Oh, David J. ;

South, Andrew P. ;

Leigh, Irene M. ;

Pourreyron, Celine ;

Cassidy, Andrew J. ;

DeAngelo, Daniel J. ;

Weinstock, David M. ;

Krop, Ian E. ;

Dillon, Deborah ;

Brock, Jane E. ;

Lazar, Alexander J. F. ;

Peto, Myron ;

Cho, Raymond J. ;

Stoeck, Alexander ;

Haines, Brian B. ;

Sathayanrayanan, Sriram ;

Rodig, Scott ;

Aster, Jon C. .

PLOS ONE, 2013, 8 (06)

[3] The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism [J].

Kopan, Raphael ;

Ilagan, Ma. Xenia G. .

CELL, 2009, 137 (02) :216-233

[4] The double-edged sword of Notch signaling in cancer [J].

South, Andrew P. ;

Cho, Raymond J. ;

Aster, Jon C. .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2012, 23 (04) :458-464

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