Cholesterol, lipoproteins and subclinical interstitial lung disease: the MESA study

被引：24

作者：

Podolanczuk, Anna J. ^{[1
]}

Raghu, Ganesh ^{[2
]}

Tsai, Michael Y. ^{[3
]}

Kawut, Steven M. ^{[4
]}

Peterson, Eric ^{[1
]}

Sonti, Rajiv ^{[1
]}

Rabinowitz, Daniel ^{[5
]}

Johnson, Craig ^{[6
]}

Barr, R. Graham ^{[1
,7
]}

Stukovsky, Karen Hinckley ^{[6
]}

Hoffman, Eric A. ^{[8
,9
,10
]}

Carr, J. Jeffrey ^{[11
]}

Ahmed, Firas S. ^{[12
]}

Jacobs, David R. ^{[13
]}

Watson, Karol ^{[14
]}

Shea, Steven J. ^{[1
,7
]}

Lederer, David J. ^{[1
,7
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Med, 622 W 168th St,PH-8, New York, NY 10032 USA

[2] Univ Washington, Dept Med, Seattle, WA 98195 USA

[3] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN USA

[4] Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Dept Med, Philadelphia, PA USA

[5] Columbia Univ, Dept Stat, New York, NY USA

[6] Univ Washington, Dept Biostat, Seattle, WA USA

[7] Columbia Univ, Med Ctr, Dept Epidemiol, New York, NY USA

[8] Univ Iowa, Carver Coll Med, Dept Radiol, Iowa City, IA USA

[9] Univ Iowa, Carver Coll Med, Dept Med, Iowa City, IA USA

[10] Univ Iowa, Carver Coll Med, Dept Biomed Engn, Iowa City, IA USA

[11] Vanderbilt Univ, Med Ctr, Dept Radiol, Nashville, TN 37235 USA

[12] Columbia Univ, Med Ctr, Dept Radiol, New York, NY USA

[13] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[14] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA USA

来源：

THORAX | 2017年 / 72卷 / 05期

基金：

美国国家卫生研究院;

关键词：

IDIOPATHIC PULMONARY-FIBROSIS; SURFACTANT PROTEIN-A; ATHEROSCLEROSIS; ASSOCIATION; BIOMARKERS; MORTALITY;

D O I：

10.1136/thoraxjnl-2016-209568

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

We investigated associations of plasma lipoproteins with subclinical interstitial lung disease (ILD) by measuring high attenuation areas (HAA: lung voxels between -600 and -250 Hounsfield units) in 6700 adults and serum MMP-7 and SP-A in 1216 adults age 45-84 without clinical cardiovascular disease in Multi-Ethnic Study of Atherosclerosis. In cross-sectional analyses, each SD decrement in high density lipoprotein cholesterol (HDL-C) was associated with a 2.12% HAA increment (95% CI 1.44% to 2.79%), a 3.53% MMP-7 increment (95% CI 0.93% to 6.07%) and a 6.37% SP-A increment (95% CI 1.35% to 11.13%), independent of demographics, smoking and inflammatory biomarkers. These findings support a novel hypothesis that HDL-C might influence subclinical lung injury and extracellular matrix remodelling.

引用

页码：472 / 474

页数：3

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