Pediatric Obesity: Etiology and Treatment

被引：51
作者：
Crocker, Melissa K. [1 ]
Yanovski, Jack A. [1 ]
机构：
[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, US PHS, Dept Hlth & Human Serv,Unit Growth & Obes, Program Dev Endocrinol & Genet,NIH, Bethesda, MD 20892 USA
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2009年 / 38卷 / 03期
关键词：
Overweight; Differential diagnosis; Pharmacotherapy; Bariatric surgery; Adiposity; Leptin; EARLY-ONSET OBESITY; BODY-MASS INDEX; GENOME-WIDE ASSOCIATION; TYPE-2; DIABETES-MELLITUS; GLUCAGON-LIKE PEPTIDE-1; GASTRIC BYPASS-SURGERY; FAMILY-BASED TREATMENT; PLASMA GHRELIN LEVELS; GROWTH-HORMONE; WEIGHT-LOSS;
D O I：
10.1016/j.ecl.2009.06.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This article reviews factors that contribute to excessive weight gain in children and outlines current knowledge regarding approaches for treating pediatric obesity. Most of the known genetic causes of obesity primarily increase energy intake. Genes regulating the leptin signaling pathway are particularly important for human energy homeostasis. Obesity is a chronic disorder that requires long-term strategies for management. The foundation for all treatments for pediatric obesity remains restriction of energy intake with lifestyle modification. There are few long-term studies of pharmacotherapeutic interventions for pediatric obesity. Bariatric surgical approaches are the most efficacious treatment but, because of their potential risks, are reserved for those with the most significant complications of obesity.
引用
收藏
页码：525 / +
页数：26
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