Immune checkpoint inhibitors-induced eosinophilic pneumonia: A case report

被引：12

作者：

Hara, Kanako ^{[1
]}

Yamasaki, Kei ^{[1
]}

Tahara, Masahiro ^{[1
]}

Kimuro, Rieko ^{[2
]}

Yamaguchi, Yudai ^{[1
]}

Suzuki, Yu ^{[1
]}

Kawabata, Hiroki ^{[1
]}

Kawanami, Toshinori ^{[1
]}

Fujimoto, Naohiro ^{[2
]}

Yatera, Kazuhiro ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Dept Resp Med, Kitakyushu, Fukuoka, Japan

[2] Univ Occupat & Environm Hlth, Dept Urol, Kitakyushu, Fukuoka, Japan

来源：

THORACIC CANCER | 2021年 / 12卷 / 05期

关键词：

eosinophilic pneumonia; immune checkpoint inhibitor; immune-related adverse event; ipilimumab; nivolumab; LUNG; IPILIMUMAB; NIVOLUMAB; DISEASES;

D O I：

10.1111/1759-7714.13848

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 78-year-old male with renal cell carcinoma was treated with combined immunotherapy of nivolumab and ipilimumab. After four courses of the treatment, a chest computed tomography (CT) revealed newly formed ground-glass opacities (GGOs) in both the lower lung lobes; drug-induced pneumonia was speculated. Eosinophil counts were elevated in both peripheral blood and bronchoalveolar lavage fluid. Both the immune checkpoint inhibitors (ICIs) were discontinued, following which the chest CT findings improved. Based on these findings, a diagnosis of ICI-induced eosinophilic pneumonia was made. Hence, clinicians should be wary of the risk of eosinophilic pneumonia during ICI-anticancer therapy.

引用

页码：720 / 724

页数：5

共 15 条

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