Advances in the pathogenesis and treatment of IBD

被引：73
作者：
Braus, Nicholas A. [2 ]
Elliott, David E. [1 ,3 ]
机构：
[1] Univ Iowa, Coll Med, Div Gastroenterol 4611 JCP, Dept Vet Affairs Med Ctr, Iowa City, IA 52242 USA
[2] Univ Iowa, Doris Duke Clin Res Fellowship Program, Carver Coll Med, Iowa City, IA 52242 USA
[3] Univ Iowa, Dept Internal Med, Div Gastroenterol & Hepatol, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA
来源：
CLINICAL IMMUNOLOGY | 2009年 / 132卷 / 01期
关键词：
Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Helminths; T lymphocytes; Interleukin; 10; 17; 4; TGF-beta; IFN-gamma; INFLAMMATORY-BOWEL-DISEASE; GENOME-WIDE ASSOCIATION; TRANSMITTED HELMINTH INFECTIONS; TRICHURIS-SUIS THERAPY; CROHNS-DISEASE; ULCERATIVE-COLITIS; PROTECTS MICE; SUSCEPTIBILITY LOCI; IMMUNE-RESPONSE; MURINE MODEL;
D O I：
10.1016/j.clim.2009.02.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Crohn's disease and ulcerative colitis are chronic remitting and relapsing inflammatory bowel diseases. We present a typical case of Crohn's disease in a young woman and discuss potential treatment options. Crohn's disease and ulcerative colitis likely result from interaction of multiple genetic and environmental risk and protective factors. Both are diseases ultimately caused by immune dysregulation. Medical therapy is with mesalamine compounds, corticosteroids, immunomodulators and/or biologics that target TNF alpha signaling or alpha 4-integrin-mediated trafficking. Investigational agents include those targeted against other cytokines and costimulatory molecules or designed to promote immune regulation such as exposure to helminths which is a focus of this review. Published by Elsevier Inc.
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页码：1 / 9
页数：9
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