Potent benzimidazolone based human β3-adrenergic receptor agonists

被引：6

作者：

Finley, Don R. ^{[1
]}

Bell, Michael G. ^{[1
]}

Borel, Anthony G. ^{[1
]}

Bloomquist, William E. ^{[1
]}

Cohen, Marlene L. ^{[1
]}

Heiman, Mark. L. ^{[1
]}

Kriauciunas, Aidas ^{[1
]}

Matthews, Donald P. ^{[1
]}

Miles, Tania ^{[1
]}

Neel, David A. ^{[1
]}

Rito, Christopher J. ^{[1
]}

Sall, Daniel J. ^{[1
]}

Shuker, Anthony J. ^{[1
]}

Stephens, Thomas W. ^{[1
]}

Tinsley, Frank C. ^{[1
]}

Winter, Mark A. ^{[1
]}

Jesudason, Cynthia D. ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 21期

关键词：

beta; 3; agonists; obesity; benzimidazolone; tachycardia; 1; receptors;

D O I：

10.1016/j.bmcl.2006.08.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological evaluation of a series of benzimidazolone beta(3) adrenergic receptor agonists are described. A trend toward the reduction of rat atrial tachycardia upon increasing steric bulk at the 3-position of the benzimidazolone moiety was observed. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5691 / 5694

页数：4

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