Is TRPA1 Burning Down TRPV1 as Druggable Target for the Treatment of Chronic Pain?

被引：40
作者：
Giorgi, Simona [1 ]
Nikolaeva-Koleva, Magdalena [1 ,2 ]
Alarcon-Alarcon, David [1 ]
Butron, Laura [1 ]
Gonzalez-Rodriguez, Sara [1 ]
机构：
[1] Univ Miguel Hernandez, Inst Invest Desarrollo & Innovac Biotecnol Sanita, Avda Univ S-N, Elche 03202, Spain
[2] Univ Miguel Hernandez, AntalGen, SL Ed Quorum 3,Parque Cient, Elche 03202, Spain
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 12期
关键词：
TRPA1; pain; inflammation; neuropathy; molecular modulation; POTENTIAL ANKYRIN 1; ION-CHANNEL TRPA1; SPINAL NERVE LIGATION; SPECIES-SPECIFIC ACTIVATION; PRIMARY AFFERENT NEURONS; PRIMARY SENSORY NEURONS; DORSAL-ROOT GANGLION; NEUROPATHIC PAIN; TRANSMEMBRANE DOMAINS; INFLAMMATORY RESPONSE;
D O I：
10.3390/ijms20122906
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Over the last decades, a great array of molecular mediators have been identified as potential targets for the treatment of chronic pain. Among these mediators, transient receptor potential (TRP) channel superfamily members have been thoroughly studied. Namely, the nonselective cationic channel, transient receptor potential ankyrin subtype 1 (TRPA1), has been described as a chemical nocisensor involved in noxious cold and mechanical sensation and as rivalling TRPV1, which traditionally has been considered as the most important TRP channel involved in nociceptive transduction. However, few TRPA1-related drugs have succeeded in clinical trials. In the present review, we attempt to discuss the latest data on the topic and future directions for pharmacological intervention.
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页数：20
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