Time-resolved singlet-oxygen luminescence detection with an efficient and practical semiconductor single-photon detector

被引：34

作者：

Boso, Gianluca ^{[1
]}

Ke, Damei ^{[2
]}

Korzh, Boris ^{[1
]}

Bouilloux, Jordan ^{[2
]}

Lange, Norbert ^{[2
]}

Zbinden, Hugo ^{[1
]}

机构：

[1] Univ Geneva, Grp Appl Phys, Chemin Pinchat 22, CH-1211 Geneva 4, Switzerland

[2] Univ Lausanne, Univ Geneva, Sch Pharmaceut Sci, Quai Ernest Ansermet 30, CH-1211 Geneva 4, Switzerland

来源：

BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

PHOTODYNAMIC THERAPY; AVALANCHE-DIODE; SPECTROSCOPY; CANCER; AZOREDUCTASE; MECHANISMS; YIELDS;

D O I：

10.1364/BOE.7.000211

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In clinical applications, such as PhotoDynamic Therapy, direct singlet-oxygen detection through its luminescence in the near-infrared range (1270 nm) has been a challenging task due to its low emission probability and the lack of suitable single-photon detectors. Here, we propose a practical setup based on a negative-feedback avalanche diode detector that is a viable alternative to the current state-of-the art for different clinical scenarios, especially where geometric collection efficiency is limited (e.g. fiber-based systems, confocal microscopy, scanning systems etc.). The proposed setup is characterized with Rose Bengal as a standard photosensitizer and it is used to measure the singlet-oxygen quantum yield of a new set of photosensitizers for site-selective photodynamic therapy. (C)2015 Optical Society of America

引用

页码：211 / 224

页数：14

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