Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy

被引：77

作者：

Cerezo, Michael ^{[1
,2
]}

Rocchi, Stephane ^{[2
]}

机构：

[1] INSERM, U981, Villejuif, France

[2] Univ Cote dAzur, INSERM, U1065, Ctr Mediterraneen Med Mol,Team 12, Nice, France

来源：

CELL DEATH & DISEASE | 2020年 / 11卷 / 11期

关键词：

TUMORAL IMMUNE RESISTANCE; ARYL-HYDROCARBON RECEPTOR; CD8(+) T-CELLS; INDOLEAMINE 2,3-DIOXYGENASE; L-ARGININE; LACTIC-ACID; TRYPTOPHAN DEGRADATION; ANTITUMOR IMMUNITY; SUPPRESSOR-CELLS; MYELOID CELLS;

D O I：

10.1038/s41419-020-03175-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

By targeting the tumor microenvironment to stimulate antitumor immunity, immunotherapies have revolutionized cancer treatment. However, many patients do not respond initially or develop secondary resistance. Based on the limited resources in the tumor microenvironment and competition between tumor and immune cells, the field of immune metabolism has produced extensive knowledge showing that targeting metabolism could help to modulate antitumor immunity. However, among all the different potentially targetable metabolic pathways, it remains unclear which have more potential to overcome resistance to immune checkpoint inhibitors. Here, we explore metabolic reprogramming in cancer cells, which might inhibit antitumor immunity, and strategies that can be used to favor the antitumor response.

引用

页数：10

共 111 条

[1] From Krebs to clinic: glutamine metabolism to cancer therapy [J].

Altman, Brian J. ;

Stine, Zachary E. ;

Dang, Chi V. .

NATURE REVIEWS CANCER, 2016, 16 (10) :619-634

[2] Lipid metabolic reprogramming in cancer cells [J].

Beloribi-Djefaflia, S. ;

Vasseur, S. ;

Guillaumond, F. .

ONCOGENESIS, 2016, 5 :e189-e189

[3] Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages [J].

Bohn, Toszka ;

Rapp, Steffen ;

Luther, Natascha ;

Klein, Matthias ;

Bruehl, Till-Julius ;

Kojima, Nobuhiko ;

Lopez, Pamela Aranda ;

Hahlbrock, Jennifer ;

Muth, Sabine ;

Endo, Shogo ;

Pektor, Stefanie ;

Brand, Almut ;

Renner, Kathrin ;

Popp, Vanessa ;

Gerlach, Katharina ;

Vogel, Dennis ;

Lueckel, Christina ;

Arnold-Schild, Danielle ;

Pouyssegur, Jacques ;

Kreutz, Marina ;

Huber, Magdalena ;

Koenig, Jochem ;

Weigmann, Benno ;

Probst, Hans-Christian ;

von Stebut, Esther ;

Becker, Christian ;

Schild, Hansjoerg ;

Schmitt, Edgar ;

Bopp, Tobias .

NATURE IMMUNOLOGY, 2018, 19 (12) :1319-+

[4]

Bosticardo M, 2001, EUR J IMMUNOL, V31, P2829, DOI 10.1002/1521-4141(200109)31:9<2829::AID-IMMU2829>3.0.CO

[5]

2-U

[6] LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells [J].

Brand, Almut ;

Singer, Katrin ;

Koehl, Gudrun E. ;

Kolitzus, Marlene ;

Schoenhammer, Gabriele ;

Thiel, Annette ;

Matos, Carina ;

Bruss, Christina ;

Klobuch, Sebastian ;

Peter, Katrin ;

Kastenberger, Michael ;

Bogdan, Christian ;

Schleicher, Ulrike ;

Mackensen, Andreas ;

Ullrich, Evelyn ;

Fichtner-Feigl, Stefan ;

Kesselring, Rebecca ;

Mack, Matthias ;

Ritter, Uwe ;

Schmid, Maximilian ;

Blank, Christian ;

Dettmer, Katja ;

Oefner, Peter J. ;

Hoffmann, Petra ;

Walenta, Stefan ;

Geissler, Edward K. ;

Pouyssegur, Jacques ;

Villunger, Andreas ;

Steven, Andre ;

Seliger, Barbara ;

Schreml, Stephan ;

Haferkamp, Sebastian ;

Kohl, Elisabeth ;

Karrer, Sigrid ;

Berneburg, Mark ;

Herr, Wolfgang ;

Mueller-Klieser, Wolfgang ;

Renner, Kathrin ;

Kreutz, Marina .

Cell Metabolism, 2016, 24 (05) :657-671

[7] Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer:: Effect on tumor-infiltrating T cells [J].

Brandacher, G ;

Perathoner, A ;

Ladurner, R ;

Schneeberger, S ;

Obrist, P ;

Winkler, C ;

Werner, ER ;

Werner-Felmayer, G ;

Weiss, HG ;

Göbel, G ;

Margreiter, R ;

Königsrainer, A ;

Fuchs, D ;

Amberger, A .

CLINICAL CANCER RESEARCH, 2006, 12 (04) :1144-1151

[8] Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival [J].

Brody, Jonathan R. ;

Costantino, Christina L. ;

Berger, Adam C. ;

Sato, Takami ;

Lisanti, Michael P. ;

Yeo, Charles J. ;

Emmons, Robert V. ;

Witkiewicz, Agnieszka K. .

CELL CYCLE, 2009, 8 (12) :1930-1934

[9] Indoleamine 2,3-dioxygenase provides adaptive resistance to immune checkpoint inhibitors in hepatocellular carcinoma [J].

Brown, Zachary J. ;

Yu, Su Jong ;

Heinrich, Bernd ;

Ma, Chi ;

Fu, Qiong ;

Sandhu, Milan ;

Agdashian, David ;

Zhang, Qianfei ;

Korangy, Firouzeh ;

Greten, Tim F. .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2018, 67 (08) :1305-1315

[10] Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes [J].

Calcinotto, Arianna ;

Filipazzi, Paola ;

Grioni, Matteo ;

Iero, Manuela ;

De Milito, Angelo ;

Ricupito, Alessia ;

Cova, Agata ;

Canese, Rossella ;

Jachetti, Elena ;

Rossetti, Monica ;

Huber, Veronica ;

Parmiani, Giorgio ;

Generoso, Luca ;

Santinami, Mario ;

Borghi, Martina ;

Fais, Stefano ;

Bellone, Matteo ;

Rivoltini, Licia .

CANCER RESEARCH, 2012, 72 (11) :2746-2756

← 1 2 3 4 5 6 7 8 9 10 →