MICROWAVE ASSISTED SYNTHESIS OF SOME 5-PHENYL-2-[(N-SUBSTITUTED PHENYL) THIOACETAMIDO]-1,3,4-OXADIAZOLES AS ANTIBACTERIAL AND ANTIOXIDANT AGENTS

被引：0

作者：

Rajasekaran, S. ^{[1
]}

Rao, Gopal Krishna ^{[1
]}

Pai, P. N. Sanjay ^{[2
]}

Vedavathy, J. ^{[1
]}

机构：

[1] Al Ameen Coll Pharm, Dept Pharmaceut Chem, Bangalore 570027, Karnataka, India

[2] Al Ameen Coll Pharm, Dept Qual Assurance, Bangalore 570027, Karnataka, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 18卷 / 03期

关键词：

1,3,4-OXADIAZOLES; 1,3,4-THIADIAZOLES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 5-phenyl-2-[(N-substituted phenyl) thioacetamido]-1,3,4-oxadiazoles (4) were synthesized and characterized on the basis of IR, NMR and mass spectral (MS) data. The title compounds were subjected to in vitro antibacterial and antioxidant activities screening. Few of them have shown significant antibacterial and antioxidant activity when compared to standard streptomycin and ascorbic acid.

引用

页码：309 / 310

页数：2

共 7 条

[1]

Hui XP, 2002, INDIAN J CHEM B, V41, P2176

[2] Antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing oxadiazoles [J].

Karthikeyan, Mari Sithambaram ;

Prasad, Dasappa Jagadeesh ;

Mahalinga, Manjathuru ;

Holla, Bantwal Shivarama ;

Kumari, Nalilu Suchetha .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (01) :25-31

[3] Synthesis and anti-mildew activity of 5-(2-aroyl)aryloxymethyl-2-phenyl-1,3,4-oxadiazoles against downy mildew of pearl millet [J].

Khanum, SA ;

Shashikanth, S ;

Sudha, BS ;

Deepak, SA ;

Shetty, HS .

PEST MANAGEMENT SCIENCE, 2004, 60 (11) :1119-1124

[4] CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITORY ACTIVITY OF 2,6 DI-T-BUTYLPHENOLS LINKED BY A SULFUR ATOM TO 1,3,4-THIADIAZOLES AND 1,3,4-OXADIAZOLES [J].

KRAMER, JB ;

BOSCHELLI, DH ;

CONNOR, DT ;

KOSTLAN, CR ;

KUIPERS, PJ ;

KENNEDY, JA ;

WRIGHT, CD ;

BORNEMEIER, DA ;

DYER, RD .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (12) :2827-2830

[5] Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure-anti-mycobacterial activities [J].

Macaev, F ;

Rusu, G ;

Pogrebnoi, S ;

Gudima, A ;

Stingaci, E ;

Vlad, L ;

Shvets, N ;

Kandemirli, F ;

Dimoglo, A ;

Reynolds, R .

BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (16) :4842-4850

[6] Synthesis and anti-inflammatory activity of 1-acylthiosemicarbazides, 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazole-3-thiones [J].

Palaska, E ;

Sahin, G ;

Kelicen, P ;

Durlu, NT ;

Altinok, G .

FARMACO, 2002, 57 (02) :101-107

[7]

Undavia NK, 2005, J INDIAN CHEM SOC, V82, P746

← 1 →