Inflammation: a mechanism of depression?

被引：82
作者：
Han, Qiu-Qin [1 ]
Yu, Jin [1 ]
机构：
[1] Fudan Univ, Shanghai Med Coll, Dept Integrat Med & Neurobiol, State Key Lab Med Neurobiol,Inst Brain Sci, Shanghai 200032, Peoples R China
来源：
NEUROSCIENCE BULLETIN | 2014年 / 30卷 / 03期
基金：
中国国家自然科学基金;
关键词：
depression; inflammation; cytokines; hypothalamic-pituitary-adrenal axis; 5-HT; neuroplasticity; NECROSIS-FACTOR-ALPHA; CENTRAL-NERVOUS-SYSTEM; PITUITARY-ADRENAL AXIS; CYTOKINE-INDUCED DEPRESSION; INTERFERON-ALPHA; GENE-EXPRESSION; MAJOR DEPRESSION; RAT-BRAIN; TNF-ALPHA; HPA-AXIS;
D O I：
10.1007/s12264-013-1439-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In recent decades, major depression has become more prevalent and research has shown that immune activation and cytokine production may be involved. This review is mainly focused on the contribution of inflammation to depression. We first briefly introduce the inflammatory biomarkers of depression, then discuss the sources of cytokines in the brain, and finally describe the neuroimmunological mechanisms underlying the association between inflammation and depression.
引用
收藏
页码：515 / 523
页数：9
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