Opportunities for Overcoming Mycobacterium tuberculosis Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy

被引：49

作者：

Torfs, Eveline ^{[1
]}

Piller, Tatiana ^{[1
]}

Cos, Paul ^{[1
]}

Cappoen, Davie ^{[1
]}

机构：

[1] Univ Antwerp, Dept Pharmaceut Sci, LMPH, Univ Pl 1, B-2610 Antwerp, Belgium

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 12期

关键词：

Mycobacterium tuberculosis; drug resistance; antimycobacterial; novel targets; non-lethal targets; host-directed therapy; LEAD OPTIMIZATION; ATP SYNTHASE; POTENT INHIBITORS; INNATE IMMUNITY; DISCOVERY; CANDIDATE; AUTOPHAGY; GENES; IDENTIFICATION; MYCOTHIOL;

D O I：

10.3390/ijms20122868

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ever-increasing incidence of drug-resistant Mycobacterium tuberculosis infections has invigorated the focus on the discovery and development of novel treatment options. The discovery and investigation of essential mycobacterial targets is of utmost importance. In addition to the discovery of novel targets, focusing on non-lethal pathways and the use of host-directed therapies has gained interest. These adjunctive treatment options could not only lead to increased antibiotic susceptibility of Mycobacterium tuberculosis, but also have the potential to avoid the emergence of drug resistance. Host-directed therapies, on the other hand, can also reduce the associated lung pathology and improve disease outcome. This review will provide an outline of recent opportunities.

引用

页数：23

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