Preimplantation genetic diagnosis

被引：150
作者：
Braude, P [1 ]
Pickering, S [1 ]
Flinter, F [1 ]
Ogilvie, CM [1 ]
机构：
[1] Guys Hosp, Ctr Preimplantat Genet Diag, London SE1 9RT, England
来源：
NATURE REVIEWS GENETICS | 2002年 / 3卷 / 12期
关键词：
D O I：
10.1038/nrg953
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Preimplantation genetic diagnosis (PGD) is an evolving technique that provides a practical alternative to prenatal diagnosis and termination of pregnancy for couples who are at substantial risk of transmitting a serious genetic disorder to their offspring. Samples for genetic testing are obtained from oocytes or cleaving embryos after in vitro fertilization. Only embryos that are shown to be free of the genetic disorders are made available for replacement in the uterus, in the hope of establishing a pregnancy. PGD has provided unique insights into aspects of reproductive genetics and early human development, but has also raised important new ethical issues about assisted human reproduction.
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收藏
页码：941 / 953
页数：13
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