Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Immunogenetic Considerations Underlying B-Cell Biology in the Development of a Pan-Subtype Influenza A Vaccine Targeting the Hemagglutinin Stem

被引：27

作者：

Andrews, Sarah F. ^{[1
]}

Graham, Barney S. ^{[1
]}

Mascola, John R. ^{[1
]}

McDermott, Adrian B. ^{[1
]}

机构：

[1] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2018年 / 10卷 / 07期

基金：

美国国家卫生研究院;

关键词：

NEUTRALIZING ANTIBODIES; DESIGN; RECOGNITION; SIGNATURES; RESPONSES; EPITOPE;

D O I：

10.1101/cshperspect.a029413

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Current influenza vaccines preferentially generate B-cell responses to the variable hemagglutinin (HA) head. Focusing vaccine-induced antibody responses on epitopes in the conserved HA stem may provide better protection against future drifted and pandemic strains. Understanding the basis for the dominant HA head and subdominant HA stem-specific responses at the level of B-cell activation and differentiation will be critical for designing vaccines that induce sustained stem-specific responses. Identifying antibody lineages with broad neutralizing activity against influenza A viruses and defining the structural mode of recognition for germline precursors of those antibodies will also guide future immunogen design.

引用

页数：8

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