Comment on 'Estimating a modified Grubb's exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler'

被引：6
作者：
Boas, David A. [1 ]
Payne, Stephen J. [2 ]
机构：
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
[2] Univ Oxford, Dept Engn Sci, Oxford OX1 3PJ, England
来源：
PHYSIOLOGICAL MEASUREMENT | 2009年 / 30卷 / 10期
关键词：
Grubb's exponent; cerebral metabolic rate of oxygen; near infrared spectroscopy; functional magnetic resonance imaging; cerebral blood flow; cerebral blood volume; CEREBRAL BLOOD-VOLUME; OXYGEN-METABOLISM; BARREL CORTEX; FLOW; ARTERIAL; LINE;
D O I：
10.1088/0967-3334/30/10/L01
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The relationship between cerebral blood volume (CBV) and blood flow (CBF) has gained widespread interest because of its utility in using functional magnetic resonance imaging and optical imaging methods to estimate the cerebral metabolic rate of oxygen (CMRO(2)). A recent paper by Leung et al (2009 Physiol. Meas. 30 1-12) nicely presents measurements relating CBV to cerebral blood flow velocity (CBFV) as measured by near infrared spectroscopy and transcranial Doppler, respectively. They suggest that this relationship cannot be inverted to estimate CBF (or CBFV) from CBV, and that doing so to estimate CMRO2 is inappropriate. We argue that these data, and other related published data, do permit the estimation of CBF from CBV and thus enable CMRO2 to be estimated when only measures of CBV and deoxygenated hemoglobin are available.
引用
收藏
页码：L9 / L11
页数：3
相关论文
共 11 条
[1]   Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy? [J].
Boas, DA ;
Strangman, G ;
Culver, JP ;
Hoge, RD ;
Jasdzewski, G ;
Poldrack, RA ;
Rosen, BR ;
Mandeville, JB .
PHYSICS IN MEDICINE AND BIOLOGY, 2003, 48 (15) :2405-2418
[2]   Calibrated functional MRI: Mapping the dynamics of oxidative metabolism [J].
Davis, TL ;
Kwong, KK ;
Weisskoff, RM ;
Rosen, BR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) :1834-1839
[3]   EFFECTS OF CHANGES IN PACO2 ON CEREBRAL BLOOD VOLUME, BLOOD FLOW, AND VASCULAR MEAN TRANSIT TIME [J].
GRUBB, RL ;
RAICHLE, ME ;
EICHLING, JO ;
TERPOGOS.MM .
STROKE, 1974, 5 (05) :630-639
[4]   A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilation [J].
Huppert, Theodore J. ;
Allen, Monica S. ;
Benav, Heval ;
Jones, Phill B. ;
Boas, David A. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2007, 27 (06) :1262-1279
[5]   Changes in human cerebral blood flow and cerebral blood volume during hypercapnia and hypocapnia measured by positron emission tomography [J].
Ito, H ;
Kanno, I ;
Ibaraki, M ;
Hatazawa, J ;
Miura, S .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (06) :665-670
[6]   Concurrent optical imaging spectroscopy and laser-Doppler Flowmetry: The relationship between blood flow, oxygenation, and volume in rodent barrel cortex [J].
Jones, M ;
Berwick, J ;
Johnston, D ;
Mayhew, J .
NEUROIMAGE, 2001, 13 (06) :1002-1015
[7]   A weighted total least-squares algorithm for fitting a straight line [J].
Krystek, Michael ;
Anton, Mathias .
MEASUREMENT SCIENCE AND TECHNOLOGY, 2007, 18 (11) :3438-3442
[8]   Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: Implications for BOLD fMRI [J].
Lee, SP ;
Duong, TQ ;
Yang, G ;
Iadecola, C ;
Kim, SG .
MAGNETIC RESONANCE IN MEDICINE, 2001, 45 (05) :791-800
[9]   Estimating a modified Grubb's exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler [J].
Leung, Terence S. ;
Tachtsidis, Ilias ;
Tisdall, Martin M. ;
Pritchard, Caroline ;
Smith, Martin ;
Elwell, Clare E. .
PHYSIOLOGICAL MEASUREMENT, 2009, 30 (01) :1-12
[10]   Increased oxygen consumption following activation of brain: Theoretical footnotes using spectroscopic data from barrel cortex [J].
Mayhew, J ;
Johnston, D ;
Martindale, J ;
Jones, M ;
Berwick, J ;
Zheng, Y .
NEUROIMAGE, 2001, 13 (06) :975-987
12