Copper catalyzed cyanomethylation reaction of 4-thiazolidinone

被引：12
作者：
Chauhan, Prakashsingh M. [1 ]
Morja, Mayur, I [1 ]
Asamdi, Manjoorahmed [2 ]
Chikhalia, Kishor H. [1 ]
机构：
[1] Veer Narmad South Gujarat Univ, Dept Chem, Surat 395007, Gujarat, India
[2] Gujarat Univ, Dept Chem, Ahmadabad 380009, Gujarat, India
来源：
TETRAHEDRON LETTERS | 2020年 / 61卷 / 50期
关键词：
4-Thiazolidinones; Cross dehydrogenative coupling (CDC); Cyanomethylation; Copper catalyst; C-C BOND; DEHYDROGENATIVE COUPLING CDC; THIAZOLIDINONE DERIVATIVES; ETHERS; ALKYNYLATION; CYANATION; OXIDATION; AMINATION; STRATEGY; DESIGN;
D O I：
10.1016/j.tetlet.2020.152601
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An effective copper catalyzed Cross Dehydrogenative Coupling (CDC) reaction of 4-thiazolidinones with acetonitrile has been developed. The described strategy undergoes radical pathway by employing copper, oxidant and easily available acetonitrile as a cyanomethyl source. Various cyanomethylated 4-thiazolidinone derivatives were obtained easily and conveniently in moderate to good yield by employing this method. Substrate scope and optimization have been carried out appropriately. Optimization was carried out through different oxidants, catalyst and various additives. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：5
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