SUN-domain and KASH-domain proteins during development, meiosis and disease

被引：75

作者：

Fridkin, A. ^{[2
]}

Penkner, A. ^{[1
]}

Jantsch, V. ^{[1
]}

Gruenbaum, Y. ^{[2
]}

机构：

[1] Univ Vienna, Dept Chromosome Biol, Max F Perutz Labs, A-1030 Vienna, Austria

[2] Hebrew Univ Jerusalem, Dept Genet, IL-91904 Jerusalem, Israel

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 09期

基金：

以色列科学基金会;

关键词：

Centrosome; cytoskeleton; Emery Dreifuss muscular dystrophy; homologous pairing; meiosis; nuclear positioning; SPINDLE POLE BODY; NUCLEAR-MEMBRANE PROTEIN; PROGRAMMED CELL-DEATH; MEIOTIC PROPHASE; BOUQUET FORMATION; MEMBER SYNE-1; ENVELOPE; MIGRATION; KLARSICHT; EMERIN;

D O I：

10.1007/s00018-008-8713-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SUN-domain proteins interact directly with KASH-domain proteins to form protein complexes that connect the nucleus to every major cytoskeleton network. SUN-KASH protein complexes are also required for attaching centrosomes to the nuclear periphery and for alignment of homologous chromosomes, their pairing and recombination in meiosis. Other functions that require SUN-domain proteins include the regulation of apoptosis and maturation and survival of the germline. Laminopathic diseases affect the distribution of the SUN-KASH complexes, and mutations in KASH-domain proteins can cause Emery Dreifuss muscular dystrophy and recessive cerebellar ataxia. This review describes our current knowledge of the role of SUN-KASH domain protein complexes during development, meiosis and disease.

引用

页码：1518 / 1533

页数：16

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