Febuxostat-associated drug reaction with eosinophilia and systemic symptoms (DRESS)

被引：36

作者：

Chou, H. -Y. ^{[1
]}

Chen, C. -B. ^{[2
,3
]}

Cheng, C. -Y. ^{[1
]}

Chen, Y. -A. ^{[4
]}

Ng, C. Y. ^{[3
,5
]}

Kuo, K. -L. ^{[2
,3
]}

Chen, W. -L. ^{[1
]}

Chen, C. -H. ^{[1
]}

机构：

[1] Chang Gung Mem Hosp, Dept Pharm, Div Clin Pharm, Linkou, Taiwan

[2] Chang Gung Mem Hosp, Dept Dermatol, Keelung, Taiwan

[3] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[4] Taipei Med Univ, Coll Pharm, Taipei, Taiwan

[5] Chang Gung Mem Hosp, Dept Dermatol, Taipei 10591, Taiwan

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2015年 / 40卷 / 06期

关键词：

adverse drug reaction; drug reaction with eosinophilia and systemic symptoms; Febuxostat; CHRONIC KIDNEY-DISEASE; HYPERSENSITIVITY REACTIONS; CLINICAL-PATTERN; ALLOPURINOL; HYPERURICEMIA; VARIABILITY; INITIATION; THERAPY;

D O I：

10.1111/jcpt.12322

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

What is known and objective: Febuxostat is recommended as an alternative drug for gouty patients with a history of allopurinol hypersensitivity or carrying the HLA-B*5801 allele. Case summary: An 81-year-old man with the medical history of gout presented to our clinic with generalized rashes for 2 days. After taking febuxostat for 2 days, he developed generalized skin rash with high fever. Laboratory tests showed elevated liver enzymes and acute kidney injury. What is known and objective: This is the first identified case of febuxostat-associated DRESS. Febuxostat should be withdrawn immediately when DRESS is observed to avoid further serious complications.

引用

页码：689 / 692

页数：4

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