Poly(3-hydroxybutyrate)/chitosan/ketoprofen or piroxicam composite microparticles: Preparation and controlled drug release evaluation

被引：31
作者：
Bazzo, G. C. [1 ]
Lemos-Senna, E. [2 ]
Pires, A. T. N. [1 ]
机构：
[1] Univ Fed Santa Catarina, Dept Quim, Grp Estudos Mat Polimer POLIMAT, BR-88040900 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Dept Ciencias Farmaceut, Lab Farmacotecn, BR-88040900 Florianopolis, SC, Brazil
来源：
CARBOHYDRATE POLYMERS | 2009年 / 77卷 / 04期
关键词：
Chitosan; Poly(3-hydroxybutyrate); Microparticles; Controlled drug release; IBUPROFEN-LOADED MICROSPHERES; LINKED CHITOSAN MICROSPHERES; PROTEIN RELEASE; FABRICATION; MORPHOLOGY;
D O I：
10.1016/j.carbpol.2009.03.006
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Poly(3-hydroxybutyrate)/chitosan/piroxicam or ketoprofen composite microparticles were prepared by the solid-in-water-in-oil emulsion-solvent evaporation technique with the aim of reducing the burst effect and controlling the drug release. Reservoir-type microparticles, composed of poly(3-hydroxybutyrate) microspheres embedded in a chitosan matrix were prepared. The size and morphological characteristics of the composite microparticles were evaluated in relation to the chitosan concentration and crosslinking with glutaraldehyde. Reservoir-type composite microparticles were obtained using 2.0% and 3.0% w/v chitosan solutions. A significant reduction in the burst effect and prolonged drug release were observed, particularly when higher chitosan and glutaraldehyde concentrations were used. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：839 / 844
页数：6
相关论文
共 16 条
[1]   Ionotropic cross-linked chitosan microspheres for controlled release of ampicillin [J].
Anal, AK ;
Stevens, WF ;
Remuñán-López, C .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 312 (1-2) :166-173
[2]   Effect of preparation conditions on morphology, drug content and release profiles of poly(hydroxybutyrate) microparticles containing piroxicam [J].
Bazzo, G. C. ;
Lemos-Senna, E. ;
Goncalves, M. C. ;
Pires, A. T. N. .
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2008, 19 (05) :914-921
[3]   Preparation and characterization of ibuprofen-loaded microspheres consisting of poly(3-hydroxybutyrate) and methoxy poly (ethylene glycol)-b-poly (D,L-lactide) blends or poly(3-hydroxybutyrate) and gelatin composites for controlled drug release [J].
Bidone, Juliana ;
Melo, Ana Paula P. ;
Bazzo, Giovana C. ;
Carmignan, Francoise ;
Soldi, Marli S. ;
Pires, Alfredo T. N. ;
Lemos-Senna, Elenara .
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2009, 29 (02) :588-593
[4]   A comparative study on the immune responses to antigens in PLA and PHB microspheres [J].
Conway, BR ;
Eyles, JE ;
Alpar, HO .
JOURNAL OF CONTROLLED RELEASE, 1997, 49 (01) :1-9
[5]   Chitosan nanoparticle as protein delivery carrier - Systematic examination of fabrication conditions for efficient loading and release [J].
Gan, Quan ;
Wang, Tao .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2007, 59 (01) :24-34
[6]   Optimized preparation of daidzein-loaded chitosan microspheres and in vivo evaluation after intramuscular injection in rats [J].
Ge, Yue-bin ;
Chen, Da-wei ;
Xie, Li-ping ;
Zhang, Rong-qing .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 338 (1-2) :142-151
[7]   Glutaraldehyde cross-linked chitosan microspheres for controlled release of centchroman [J].
Gupta, K. C. ;
Jabrail, Fawzl Habeeb .
CARBOHYDRATE RESEARCH, 2007, 342 (15) :2244-2252
[8]   Effect of the microencapsulation of nanoparticles on the reduction of burst release [J].
Hasan, A. Sheikh ;
Socha, M. ;
Lamprecht, A. ;
El Ghazouani, F. ;
Sapin, A. ;
Hoffman, A. ;
Maincent, P. ;
Ubrich, N. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 344 (1-2) :53-61
[9]   Tailoring of the external and internal morphology of poly-3-hydroxy butyrate microparticles [J].
Martin, MA ;
Miguens, FC ;
Rieumont, J ;
Sanchez, R .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2000, 17 (02) :111-116
[10]   Applicability of various amphiphilic polymers to the modification of protein release kinetics from biodegradable reservoir-type microspheres [J].
Morita, T ;
Horikiri, Y ;
Suzuki, T ;
Yoshino, H .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2001, 51 (01) :45-53
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