Inhibitors of bacterial signal peptidase: A series of 6-(substituted oxyethyl)penems

被引：36

作者：

Allsop, A ^{[1
]}

Brooks, G ^{[1
]}

Edwards, PD ^{[1
]}

Kaura, AC ^{[1
]}

Southgate, R ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 09期

关键词：

D O I：

10.7164/antibiotics.49.921

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A series of 6-(substituted oxyethyl)penem esters having the (5S) stereochemistry which are potent inhibitors of Escherichia coli leader peptidase is described. Structure-activity relationships are discussed.

引用

页码：921 / 928

页数：8

共 10 条

[1] PENEM INHIBITORS OF BACTERIAL SIGNAL PEPTIDASE [J].

ALLSOP, AE ;

BROOKS, G ;

BRUTON, G ;

COULTON, S ;

EDWARDS, PD ;

HATTON, IK ;

KAURA, AC ;

MCLEAN, SD ;

PEARSON, ND ;

SMALE, TC ;

SOUTHGATE, R .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (05) :443-448

[2]

BROOM NJP, 1983, Patent No. 2037277

[3]

DALBEY RE, 1985, J BIOL CHEM, V260, P5925

[4] PHOTOINDUCED ISOMERIZATION OF A 5,6-TRANS-PENEM TO A CIS-PENEM [J].

IWATA, H ;

TANAKA, R ;

IMAJO, S ;

OYAMA, Y ;

ISHIGURO, M .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (05) :285-287

[5] TOTAL SYNTHESIS OF THE IMMUNOSUPPRESSANT (-)-FK-506 [J].

JONES, TK ;

MILLS, SG ;

REAMER, RA ;

ASKIN, D ;

DESMOND, R ;

VOLANTE, RP ;

SHINKAI, I .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (03) :1157-1159

[6] AN EFFICIENT SYNTHESIS OF 2-SUBSTITUTED-THIO-6-HYDROXYETHYL-PENEM-3-CARBOXYLIC ACIDS VIA 2-THIOXOPENAMS [J].

LEANZA, WJ ;

DININNO, F ;

MUTHARD, DA ;

WILKENING, RR ;

WILDONGER, KJ ;

RATCLIFFE, RW ;

CHRISTENSEN, BG .

TETRAHEDRON, 1983, 39 (15) :2505-2513

[7]

MISRA R, 1992, EMERGING TARGETS ANT, P163

[8]

MOORE KE, 1987, J BIOL CHEM, V262, P8806

[9] THE COMPLETE GENERAL SECRETORY PATHWAY IN GRAM-NEGATIVE BACTERIA [J].

PUGSLEY, AP .

MICROBIOLOGICAL REVIEWS, 1993, 57 (01) :50-108

[10]

WOLFE PB, 1983, J BIOL CHEM, V258, P2073

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