Inhibitors of bacterial signal peptidase: A series of 6-(substituted oxyethyl)penems

被引：36

作者：

Allsop, A ^{[1
]}

Brooks, G ^{[1
]}

Edwards, PD ^{[1
]}

Kaura, AC ^{[1
]}

Southgate, R ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 09期

关键词：

D O I：

10.7164/antibiotics.49.921

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A series of 6-(substituted oxyethyl)penem esters having the (5S) stereochemistry which are potent inhibitors of Escherichia coli leader peptidase is described. Structure-activity relationships are discussed.

引用

页码：921 / 928

页数：8

共 10 条

[1] PENEM INHIBITORS OF BACTERIAL SIGNAL PEPTIDASE
ALLSOP, AE
BROOKS, G
BRUTON, G
COULTON, S
EDWARDS, PD
HATTON, IK
KAURA, AC
MCLEAN, SD
PEARSON, ND
SMALE, TC
SOUTHGATE, R
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (05) : 443 - 448
[2] BROOM NJP, 1983, Patent No. 2037277
[3] DALBEY RE, 1985, J BIOL CHEM, V260, P5925
[4] PHOTOINDUCED ISOMERIZATION OF A 5,6-TRANS-PENEM TO A CIS-PENEM
IWATA, H
TANAKA, R
IMAJO, S
OYAMA, Y
ISHIGURO, M
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (05) : 285 - 287
[5] TOTAL SYNTHESIS OF THE IMMUNOSUPPRESSANT (-)-FK-506
JONES, TK
MILLS, SG
REAMER, RA
ASKIN, D
DESMOND, R
VOLANTE, RP
SHINKAI, I
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (03) : 1157 - 1159
[6] AN EFFICIENT SYNTHESIS OF 2-SUBSTITUTED-THIO-6-HYDROXYETHYL-PENEM-3-CARBOXYLIC ACIDS VIA 2-THIOXOPENAMS
LEANZA, WJ
DININNO, F
MUTHARD, DA
WILKENING, RR
WILDONGER, KJ
RATCLIFFE, RW
CHRISTENSEN, BG
[J]. TETRAHEDRON, 1983, 39 (15) : 2505 - 2513
[7] MISRA R, 1992, EMERGING TARGETS ANT, P163
[8] MOORE KE, 1987, J BIOL CHEM, V262, P8806
[9] THE COMPLETE GENERAL SECRETORY PATHWAY IN GRAM-NEGATIVE BACTERIA
PUGSLEY, AP
[J]. MICROBIOLOGICAL REVIEWS, 1993, 57 (01) : 50 - 108
[10] WOLFE PB, 1983, J BIOL CHEM, V258, P2073

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