Synthesis of a Novel Class of gem-Phosphonate-Phosphates by Reductive Cleavage of the Isoxazolidine Ring

被引：8

作者：

Bortolini, Olga ^{[1
]}

Mulani, Iqbal ^{[2
]}

De Nino, Antonio ^{[2
]}

Maiuolo, Loredana ^{[2
]}

Melicchio, Alessandro ^{[2
]}

Russo, Beatrice ^{[2
]}

Granchi, Donatella ^{[3
]}

机构：

[1] Univ Ferrara, Dipartimento Sci Chim & Farmaceut, I-44121 Ferrara, Italy

[2] Univ Calabria, Dipartimento Chim & Tecnol Chim, I-87036 Arcavacata Di Rende, CS, Italy

[3] Ist Ortoped Rizzoli, Lab Fisiopatol Ortoped & Med Rigenerat, I-40136 Bologna, Italy

来源：

CURRENT ORGANIC SYNTHESIS | 2014年 / 11卷 / 03期

关键词：

Apolipoprotein E; bisphosphonates; gem-phosphonate-phosphate rearrangement; isoxazolidines; ring opening; transition-metal carbonyls; 1,3-DIPOLAR CYCLOADDITION; NITRONES; BISPHOSPHONATES; REARRANGEMENT; ACIDS; MILD;

D O I：

10.2174/15701794113109990061

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of gem-phosphonate-phosphates bearing N-alkyl groups and aromatic substituents has been prepared by reductive cleavage of the isoxazolidine ring with metal carbonyls, using the gem-phosphonate-phosphate rearrangement.

引用

页码：461 / 465

页数：5

共 23 条

[1]

AURICH HG, 1995, SYNTHESIS-STUTTGART, P1171

[2] CYCLO-ADDITION OF CHIRAL NITRONES - ASYMMETRIC SYNTHESIS OF ISOXAZOLIDINES [J].