Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: Potential new target for cancer treatment

被引：40
作者：
Greenberg, Edward F. [1 ,2 ]
Lavik, Andrew R. [1 ]
Distelhorst, Clark W. [1 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Div Hematol Oncol, Case Comprehens Canc Ctr,Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA
[2] Metrohlth Med Ctr, Cleveland, OH USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2014年 / 1843卷 / 10期
关键词：
Bcl-2; Inositol 1,4,5-trisphosphate receptor; Apoptosis; Cancer; Chronic lymphocytic leukemia; Lymphocyte; ENDOPLASMIC-RETICULUM; MITOCHONDRIAL CALCIUM; NEGATIVE SELECTION; PROTEIN FAMILY; IMMATURE THYMOCYTES; POSITIVE SELECTION; COUPLING DOMAIN; CELL-SURVIVAL; CA2+ TRANSFER; BH4; DOMAIN;
D O I：
10.1016/j.bbamcr.2014.03.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The anti-apoptotic protein Bcl-2 is a versatile regulator of cell survival. Its interactions with its own pro-apoptotic family members are widely recognized for their role in promoting the survival of cancer cells. These interactions are thus being targeted for cancer treatment. Less widely recognized is the interaction of Bcl-2 with the inositol 1,4,5-trisphosphate receptor (InsP(3)R), an InsP(3)-gated Ca2+ channel located on the endoplasmic reticulum. The nature of this interaction, the mechanism by which it controls Ca2+ release from the ER, its role in T-cell development and survival, and the possibility of targeting it as a novel cancer treatment strategy are summarized in this review. This article is part of a Special Issue entitled: Calcium signaling in health and disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：2205 / 2210
页数：6
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