Shared T cell receptor chains in blood memory CD4+ T cells of narcolepsy type 1 patients

被引：8

作者：

Beltran, Eduardo ^{[1
,2
]}

Xuan-Hung Nguyen ^{[3
,4
]}

Queriault, Clemence ^{[3
]}

Barateau, Lucie ^{[5
]}

Dauvilliers, Yves ^{[5
]}

Dornmair, Klaus ^{[1
,2
]}

Liblau, Roland S. ^{[3
]}

机构：

[1] Biomed Ctr, Inst Clin Neuroimmunol, Munich, Germany

[2] Hosp Ludwig Maximilian Univ Munich, Munich, Germany

[3] Univ Toulouse, UPS, INSERM, CPTP,CNRS, Toulouse, France

[4] Vinmec Int Hosp, Vinmec Res Inst Stem Cell & Gene Technol VRISG, Hanoi, Vietnam

[5] CHU Montpellier, Gui de Chauliac Hosp, Natl Reference Ctr Orphan Dis Narcolepsy Idiopath, Dept Neurol,INSERM,U1061, Montpellier, France

来源：

JOURNAL OF AUTOIMMUNITY | 2019年 / 100卷

关键词：

PROTECTION; NEURONS; RISK;

D O I：

10.1016/j.jaut.2019.03.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Convergent evidence points to the involvement of T cells in the pathogenesis of narcolepsy type 1 (NT1). Here, we hypothesized that expanded disease-specific T cell clones could be detected in the blood of NT1 patients. We compared the TCR repertoire of circulating antigen-experienced CD4(+) and CD8(+) T cells from 13 recently diagnosed NT1 patients and 11 age-, sex-, and HLA-DQB1(star)06:02-matched healthy controls. We detected a bias in the usage of TRAV3 and TRAV8 families, with public CDR3 alpha motifs only present in CD4(+) T cells from patients with NT1. These findings may offer a unique tool to identify disease-relevant antigens.

引用

页码：1 / 6

页数：6

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