Treadmill training as an augmentation treatment for Alzheimer's disease: a pilot randomized controlled study

被引：37

作者：

Arcoverde, Cynthia ^{[1
]}

Deslandes, Andrea ^{[2
]}

Moraes, Helena ^{[1
]}

Almeida, Cloyra ^{[1
]}

de Araujo, Narahyana Bom ^{[1
]}

Vasques, Paulo Eduardo ^{[1
]}

Silveira, Heitor ^{[1
]}

Laks, Jerson ^{[1
,3
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Psiquiatria, Rio De Janeiro, RJ, Brazil

[2] Fundacao Amparo Pesquisa Estado Rio de Janeiro, Rio De Janeiro, RJ, Brazil

[3] Inst Vital Brazil, Ctr Estudo Pesquisa Envelhecimento, Brazilian Natl Res Council, Campanha, MG, Brazil

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2014年 / 72卷 / 03期

关键词：

Alzheimer's disease; aerobic exercise; physical training; cognitive function; functional capacity; PHYSICAL-ACTIVITY; COGNITIVE FUNCTIONS; EXERCISE; DEMENTIA; PROGRAM; RISK; RESIDENTS; BALANCE; HEALTH;

D O I：

10.1590/0004-282X20130231

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: To assess the effect of aerobic exercise on the cognition and functional capacity in Alzheimer's disease (AD) patients. Method: Elderly (n=20) with mild dementia (NINCDS-ADRDA/CDR1) were randomly assigned to an exercise group (EG) on a treadmill (30 minutes, twice a week and moderate intensity of 60% VO2max) and control group (GC) 10 patients. The primary outcome measure was the cognitive function using Cambridge Cognitive Examination (CAMCOG). Specifics instruments were also applied to evaluate executive function, memory, attention and concentration, cognitive flexibility, inhibitory control and functional capacity. Results: After 16 weeks, the EG showed improvement in cognition CAMCOG whereas the CG declined. Compared to the CG, the EG presented significant improvement on the functional capacity. The analysis of the effect size has shown a favorable response to the physical exercise in all dependent variables. Conclusion: Walking on treadmill may be recommended as an augmentation treatment for patients with AD.

引用

页码：190 / 196

页数：7

共 30 条

[1] Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease [J].

Adlard, PA ;

Perreau, VM ;

Pop, V ;

Cotman, CW .

JOURNAL OF NEUROSCIENCE, 2005, 25 (17) :4217-4221

[2] CORNELL SCALE FOR DEPRESSION IN DEMENTIA [J].

ALEXOPOULOS, GS ;

ABRAMS, RC ;

YOUNG, RC ;

SHAMOIAN, CA .

BIOLOGICAL PSYCHIATRY, 1988, 23 (03) :271-284

[3]

[Anonymous], 1981, Wechsler Adult Intelligence Scale-Revised

[4] Role of physical activity on the maintenance of cognition and activities of daily living in elderly with Alzheimer's disease [J].

Arcoverde, Cynthia ;

Deslandes, Andrea ;

Rangel, Aryce ;

Rangel, Andreza ;

Pavao, Robson ;

Nigri, Fortunee ;

Engelhardt, Eliasz ;

Laks, Jerson .

ARQUIVOS DE NEURO-PSIQUIATRIA, 2008, 66 (2B) :323-327

[5]

Bentham P, 2004, LANCET, V363, P2105

[6]

Berg K, 1996, CLIN GERIATR MED, V12, P705

[7]

Bottino C., 1999, Entrevista estruturada para o diagnostico de transtornos mentais em idosos - CAMDEX. The Cambridge examination for mental disorders of the elderly. Brazilian version (translated and adapted on behalf of the editors)

[8] Cardiorespiratory fitness and brain atrophy in early Alzheimer disease [J].

Burns, J. M. ;

Cronk, B. B. ;

Anderson, H. S. ;

Donnelly, J. E. ;

Thomas, G. P. ;

Harsha, A. ;

Brooks, W. M. ;

Swerdlow, R. H. .

NEUROLOGY, 2008, 71 (03) :210-216

[9] The effects of a walking/talking program on communication, ambulation, and functional status in residents with Alzheimer disease [J].

Cott, CA ;

Dawson, P ;

Sidani, T ;

Wells, T .

ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2002, 16 (02) :81-87

[10] Exercise and Mental Health: Many Reasons to Move [J].

Deslandes, Andrea ;

Moraes, Helena ;

Ferreira, Camila ;

Veiga, Heloisa ;

Silveira, Heitor ;

Mouta, Raphael ;

Pompeu, Fernando A. M. S. ;

Freire Coutinho, Evandro Silva ;

Laks, Jerson .

NEUROPSYCHOBIOLOGY, 2009, 59 (04) :191-198

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