Hypertension in black people: pathophysiology and therapeutic aspects

被引:13
作者
Lopes, AA [1 ]
机构
[1] Univ Fed Bahia, Fac Med, Dept Med, Salvador, BA, Brazil
关键词
black people; blood pressure; ethnicity; treatment;
D O I
10.1038/sj.jhh.1001333
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Salt sensitivity is regarded as an important contributor to the higher risk of hypertension in black people as compared with whites. This finding is in agreement with a better response to diuretics than to monotherapy with angiotensin-converting enzyme (ACE) inhibitor in black subjects. It is important to remember that the hypotensive effect of ACE inhibitor is augmented in patients on a thiazide diuretic. Moreover, the antihypertensive response to a specific drug varies among black patients. Thus, ACE inhibitors should also be viewed as important options to treat hypertensive black subjects. Results from clinical trials support an emphasis on lifestyle modification and a more intensive blood pressure lowering by pharmacological interventions to reduce the large black-white gap in cardiovascular events and end-stage renal disease (ESRD) attributed to hypertension.
引用
收藏
页码:S11 / S12
页数:2
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