The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS)

被引：166
作者：
Beebe, AM
Cua, DJ
Malefyt, RD
机构：
[1] DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA
[2] DNAX Res Inst Mol & Cellular Biol Inc, Dept Expt Pathol, Palo Alto, CA 94304 USA
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2002年 / 13卷 / 4-5期
关键词：
IL-10; inflammation; regulatory T cells; SLE; EAE;
D O I：
10.1016/S1359-6101(02)00025-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin-10 (IL-10) is an immunoregulatory cytokine that plays a crucial role in inflammatory and immune reactions. It has potent anti-inflammatory and immunosuppressive activities on myeloid cell functions which forms a solid basis for its use in acute and chronic inflammatory diseases. Here, we discuss the role of IL-10 in autoimmune diseases and examine its beneficial effects in cellular-based autoimmune diseases such as multiple sclerosis (MS) or its involvement in humoral-based autoimmune diseases such as systemic lupus erythematosus (SLE). Inhibition of the immune stimulatory activities of IL-10 may provide novel approaches in the treatment of Immoral autoimmune diseases, infectious diseases and cancer. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：403 / 412
页数：10
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