Synthesis of 19-Nor-Vitamin D A-Ring Synthons via Ring-Closing Olefin Metathesis

被引：7

作者：

Nagai, Yu ^{[1
]}

Tanami, Tomoe ^{[1
]}

Abe, Junko ^{[1
]}

Nagai, Hazuki ^{[2
]}

Hamamizu, Toru ^{[2
]}

Kominato, Kaichiro ^{[2
]}

Iida, Keisuke ^{[1
]}

Nagasawa, Kazuo ^{[1
]}

机构：

[1] Tokyo Univ Agr & Technol, Fac Technol, Dept Biotechnol & Life Sci, Koganei, Tokyo 1848588, Japan

[2] MicroBiopharm Japan Co Ltd, Div Res & Dev, Proc Dev Dept, Iwata, Shizuoka 4380078, Japan

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 3卷 / 09期

关键词：

alkenes; 19-nor-vitamin D; palladium; ring-closing metathesis; Suzuki-Miyaura reaction; VITAMIN-D; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; BIOLOGICAL-ACTIVITY; 25-DIHYDROXY-19-NORVITAMIN D-3; EFFICIENT SYNTHESIS; JULIA OLEFINATION; D ANALOGS; DERIVATIVES; HYDROXY;

D O I：

10.1002/ajoc.201402109

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

19-Nor-vitamin D A-ring synthons were obtained from linear olefins by means of ring-closing olefin metathesis followed by palladium-catalyzed isomerization of the endocyclic olefin product to an exocyclic olefin.

引用

页码：994 / 999

页数：6

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