CD8+ T cells reduce in vitro interferon-γ production in Theiler's murine encephalomyelitis virus-induced demyelinating disease model

被引：0

作者：

Denton, PW ^{[1
]}

Tello, CM ^{[1
]}

Melvold, RW ^{[1
]}

机构：

[1] Univ N Dakota, Sch Med & Hlth Sci, Dept Microbiol & Immunol, Grand Forks, ND 58203 USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2004年 / 10卷 / 04期

关键词：

autoimmune demyelination; interferon-gamma; multiple sclerosis; regulatory CD8+T cells; TMEV;

D O I：

10.1191/1352458504ms1054oa

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In the Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease model for multiple sclerosis, regulatory CD8 + T cells prevent demyelinating disease and reduce in vivo interferon (IFN)-gamma production by anti-TMEV CD4 + blast cells in BALB/c mice. We describe here that regulatory CD8 + T cells reduce in vitro IFN-gamma production by lymph node cells from both TMEV and fowl gamma globulin immunized mice without affecting interleukin (IL)-4, IL-10, tumour growth factor-beta or tumour necrosis factor-alpha production.

引用

页码：370 / 375

页数：6

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