Role of tumor and host autophagy in cancer metabolism

被引：250

作者：

Poillet-Perez, Laura ^{[1
]}

White, Eileen ^{[1
,2
]}

机构：

[1] Rutgers Canc Inst New Jersey, New Brunswick, NJ 08903 USA

[2] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA

来源：

GENES & DEVELOPMENT | 2019年 / 33卷 / 11-12期

基金：

美国国家卫生研究院;

关键词：

autophagy; cancer; metabolism; PANCREATIC STELLATE CELLS; ARGININE DEPRIVATION; PROMOTES GROWTH; ARGINASE I; PROGRESSION; MITOPHAGY; MECHANISMS; PROTEIN; GENE; P53;

D O I：

10.1101/gad.325514.119

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macroautophagy (referred to here as autophagy) degrades and recycles cytoplasmic constituents to sustain cellular and mammalian metabolism and survival during starvation. Deregulation of autophagy is involved in numerous diseases, such as cancer. Cancers up-regulate autophagy and depend on it for survival, growth, and malignancy in a tumor cell-autonomous fashion. Recently, it has become apparent that autophagy in host tissues as well as the tumor cells themselves contribute to tumor growth. Understanding how autophagy regulates metabolism and tumor growth has revealed newessential tumor nutrients, where they come from, and how they are supplied and used, which can now be targeted for cancer therapy.

引用

页码：610 / 619

页数：10

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