Impact of porcine circovirus type 2 (PCV2) infection on hepatitis E virus (HEV) infection and transmission under experimental conditions

被引：11
|
作者：
Salines, Morgan [1 ,2 ]
Andraud, Mathieu [1 ,2 ]
Pellerin, Marie [3 ,4 ,5 ]
Bernard, Cecilia [1 ,2 ]
Grasland, Beatrice [1 ,2 ]
Pavio, Nicole [3 ,4 ,5 ]
Rose, Nicolas [1 ,2 ]
机构：
[1] French Agcy Food Environm & Occupat Hlth & Safety, ANSES, Ploufragan Plouzane Lab, F-22440 Ploufragan, France
[2] Bretagne Loire Univ, F-35000 Rennes, France
[3] ANSES, Lab Anim Hlth, UMR Virol 1161, F-94706 Maisons Alfort, France
[4] INRA, UMR Virol 1161, F-94706 Maisons Alfort, France
[5] Natl Vet Sch Alfort, UMR Virol 1161, F-94706 Maisons Alfort, France
来源：
VETERINARY MICROBIOLOGY | 2019年 / 234卷
关键词：
Co-infection; PCV2; HEV; Infection kinetic; Transmission experiment; PIGS; PMWS;
D O I：
10.1016/j.vetmic.2019.05.010
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Hepatitis E virus is a zoonotic pathogen for which pigs have been identified as the main reservoir in industrialised countries. HEV infection dynamics in pig herds and pigs are influenced by several factors, including herd practices and possibly co-infection with immunomodulating viruses. This study therefore investigates the impact of porcine circovirus type 2 (PCV2) on HEV infection and transmission through experimental HEV/PCV2 co-infection of specific-pathogen-free pigs. No statistical difference between HEV-only and HEV/PCV2-infected animals was found for either the infectious period or the quantity of HEV shed in faeces. The HEV latency period was shorter for HEV/PCV2 co-infected pigs than for HEV-only infected pigs (11.6 versus 12.3 days). Its direct transmission rate was three times higher in cases of HEV/PCV2 co-infection than in cases of HEV-only infection (0.12 versus 0.04). On the other hand, the HEV transmission rate through environmental accumulation was lower in cases of HEV/PCV2 co-infection (4.3.10(-6) versus 1.5.10(-5) g/RNA copies/day for HEV-only infected pigs). The time prior to HEV seroconversion was 1.9 times longer in HEV/PCV2 co-infected pigs (49.4 versus 25.6 days for HEV-only infected pigs). In conclusion, our study shows that PCV2 affects HEV infection and transmission in pigs under experimental conditions.
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页码：1 / 7
页数：7
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