Metastasis: from dissemination to organ-specific colonization

被引：2003

作者：

Nguyen, Don X. ^{[1
]}

Bos, Paula D. ^{[1
]}

Massague, Joan ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA

[2] Howard Hughes Med Inst, Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 04期

基金：

美国国家卫生研究院;

关键词：

BREAST-CANCER METASTASIS; CYTOKERATIN-POSITIVE CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; BONE-MARROW; LUNG METASTASIS; TUMOR DORMANCY; TGF-BETA; PROSTATE-CANCER; STEM-CELLS; NEOPLASTIC TRANSFORMATION;

D O I：

10.1038/nrc2622

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis to distant organs is an ominous feature of most malignant tumours but the natural history of this process varies in different cancers. The cellular origin, intrinsic properties of the tumour, tissue affinities and circulation patterns determine not only the sites of tumour spread, but also the temporal course and severity of metastasis to vital organs. Striking disparities in the natural progression of different cancers raise important questions about the evolution of metastatic traits, the genetic determinants of these properties and the mechanisms that lead to the selection of metastatic cells.

引用

页码：274 / U65

页数：12

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