Metastasis: from dissemination to organ-specific colonization

被引：2003
作者：
Nguyen, Don X. [1 ]
Bos, Paula D. [1 ]
Massague, Joan [1 ,2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA
[2] Howard Hughes Med Inst, Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
来源：
NATURE REVIEWS CANCER | 2009年 / 9卷 / 04期
基金：
美国国家卫生研究院;
关键词：
BREAST-CANCER METASTASIS; CYTOKERATIN-POSITIVE CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; BONE-MARROW; LUNG METASTASIS; TUMOR DORMANCY; TGF-BETA; PROSTATE-CANCER; STEM-CELLS; NEOPLASTIC TRANSFORMATION;
D O I：
10.1038/nrc2622
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metastasis to distant organs is an ominous feature of most malignant tumours but the natural history of this process varies in different cancers. The cellular origin, intrinsic properties of the tumour, tissue affinities and circulation patterns determine not only the sites of tumour spread, but also the temporal course and severity of metastasis to vital organs. Striking disparities in the natural progression of different cancers raise important questions about the evolution of metastatic traits, the genetic determinants of these properties and the mechanisms that lead to the selection of metastatic cells.
引用
收藏
页码：274 / U65
页数：12
相关论文
共 119 条
[31]   Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma [J].
Garraway, LA ;
Widlund, HR ;
Rubin, MA ;
Getz, G ;
Berger, AJ ;
Ramaswamy, S ;
Beroukhim, R ;
Milner, DA ;
Granter, SR ;
Du, JY ;
Lee, C ;
Wagner, SN ;
Li, C ;
Golub, TR ;
Rimm, DL ;
Meyerson, ML ;
Fisher, DE ;
Sellers, WR .
NATURE, 2005, 436 (7047) :117-122
[32]   The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 [J].
Gregory, Philip A. ;
Bert, Andrew G. ;
Paterson, Emily L. ;
Barry, Simon C. ;
Tsykin, Anna ;
Farshid, Gelareh ;
Vadas, Mathew A. ;
Khew-Goodall, Yeesim ;
Goodall, Gregory J. .
NATURE CELL BIOLOGY, 2008, 10 (05) :593-601
[33]   The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers [J].
Guo, Chunguang ;
Sah, Jerome F. ;
Beard, Lydia ;
Willson, James K. V. ;
Markowitz, Sanford D. ;
Guda, Kishore .
GENES CHROMOSOMES & CANCER, 2008, 47 (11) :939-946
[34]   ID genes mediate tumor reinitiation during breast cancer lung metastasis [J].
Gupta, Gaorav P. ;
Perk, Jonathan ;
Acharyya, Swarnali ;
de Candia, Paola ;
Mittal, Vivek ;
Todorova-Manova, Katia ;
Gerald, William L. ;
Brogi, Edi ;
Benezra, Robert ;
Massague, Joan .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (49) :19506-19511
[35]   Mediators of vascular remodelling co-opted for sequential steps in lung metastasis [J].
Gupta, Gaorav P. ;
Nguyen, Don X. ;
Chiang, Anne C. ;
Bos, Paula D. ;
Kim, Juliet Y. ;
Nadal, Cristina ;
Gomis, Roger R. ;
Manova-Todorova, Katia ;
Massague, Joan .
NATURE, 2007, 446 (7137) :765-U2
[36]   Cancer metastasis:: Building a framework [J].
Gupta, Gaorav P. ;
Massague, Joan .
CELL, 2006, 127 (04) :679-695
[37]   The melanocyte differentiation program predisposes to metastasis after neoplastic transformation [J].
Gupta, PB ;
Kuperwasser, C ;
Brunet, JP ;
Ramaswamy, S ;
Kuo, WL ;
Gray, JW ;
Naber, SP ;
Weinberg, RA .
NATURE GENETICS, 2005, 37 (10) :1047-1054
[38]   The hallmarks of cancer [J].
Hanahan, D ;
Weinberg, RA .
CELL, 2000, 100 (01) :57-70
[39]   Metastatic patterns in adenocarcinoma [J].
Hess, KR ;
Varadhachary, GR ;
Taylor, SH ;
Wei, W ;
Raber, MN ;
Lenzi, R ;
Abbruzzese, JL .
CANCER, 2006, 106 (07) :1624-1633
[40]   The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase [J].
Hiratsuka, Sachie ;
Watanabe, Akira ;
Sakurai, Yoshiko ;
Akashi-Takamura, Sachiko ;
Ishibashi, Sachie ;
Miyake, Kensuke ;
Shibuya, Masabumi ;
Akira, Shizuo ;
Aburatani, Hiroyuki ;
Maru, Yoshiro .
NATURE CELL BIOLOGY, 2008, 10 (11) :1349-U229
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