Treatment of systemic sclerosis

被引：0
作者：
van den Hoogen, F. H. J. [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, NL-6500 HB Nijmegen, Netherlands
[2] Rheumatol Ctr St Maartensklin, Nijmegen, Netherlands
来源：
ZEITSCHRIFT FUR RHEUMATOLOGIE | 2006年 / 65卷 / 04期
关键词：
systemic sclerosis; scleroderma; therapy; immunesuppresion;
D O I：
10.1007/s00393-006-0075-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Systemic sclerosis (SSc, scleroderma) is a multisystem disease with a bad prognosis. No drugs have been shown to cure this disease. In view of its pathogenesis, in which immune responses are presumed to play an important role, immune suppressive therapies are widely applied in the treatment of SSc. Recent placebo-controlled trials with cyclophosphamide in patients with SSc complicated by alveolitis, show a modest but significant difference in pulmonary function tests in favour for the cyclophosphamide treated group. Treatment with prostacyclin analogues and endothelin-1 receptor antagonists appear to stabilize pulmonary arterial hypertension, a thus far fatal complication of SSc.
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收藏
页码：306 / +
页数：4
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