Accommodation and antibodies

被引：14

作者：

Dehoux, Jean-Paul ^{[1
]}

Gianello, Pierre ^{[1
]}

机构：

[1] Univ Catholique Louvain, Fac Med, Expt Surg Lab, B-1200 Brussels, Belgium

来源：

TRANSPLANT IMMUNOLOGY | 2009年 / 21卷 / 02期

关键词：

Accommodation; Allotransplantation; Xenotransplantation; Humoral rejection; PORCINE ENDOTHELIAL-CELLS; ACUTE VASCULAR REJECTION; LONG-TERM SURVIVAL; ALPHA-MEDIATED APOPTOSIS; MEMBRANE ATTACK COMPLEX; IN-VITRO ACCOMMODATION; NF-KAPPA-B; HEME OXYGENASE-1; CARBON-MONOXIDE; ORGAN-TRANSPLANTATION;

D O I：

10.1016/j.trim.2008.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Accommodation refers to the condition in which an organ transplant functions normally by acquiring resistance to immune-mediated injury (especially), despite the presence of anti-transplant antibodies in the recipient. This status is associated with several modifications in the recipient as well as in the graft, such as previous depletion of anti-graft antibodies and their slow return once the graft is placed; expression of several protective genes in the graft; a Th2 immune response in the recipient; and inhibition of the membrane attack complex of complement (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：106 / 110

页数：5

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