Metabolic syndrome is also known as syndrome X, insulin resistance syndrome, syndrome of hypertension or syndrome of catecholamine excess. Population studies in recent years have shown that metabolic syndrome (SMet) would double the risk of adverse cardiovascular events [1] and non-diabetic patients would increase 5 times the risk of developing type 2 diabetes [2]. Clinical identification of the metabolic syndrome is based on the evaluation of abdominal obesity, dyslipidemia, arterial hypertension and glucose intolerance. Among the essential criteria of the metabolic syndrome, according to WHO, insulin resistance and insulin estimating consumption or its substitutes have an important role. The work itself consists of two separate studies, one retrospective, performed during the period December 2012 - December 2013, comprising a total of 2672 patients suffering from SMet admitted to the Medical Clinic 1 Hospital CF Constanta and a prospective study that included 21 patients who were diagnosed with SMet prepared a worksheet similar clinical observation sheet and it has imposed a 1500 calorie diet / day, personalized diet according to food preferences of each. Afterward it has been watched blood pressure, serum glucose, triglycerides, total cholesterol and LDL cholesterol to 3, 6, 9 and 12 months. It was observed that weight loss under a restrictive diet to 1500 calories / day resulted in: - lowering systolic blood pressure to a total of 15 patients, reaching these values <140 mm Hg, - total cholesterol levels dropped below diet to a total of 16 patients, they reaching the threshold of 200 mg / dl (even <200 mg / dl) - Proportional to the total cholesterol, decreased LDL-cholesterol values also, which has reduced atherogenic risk in these patients