A comparison of oleamide in the brains of hibernating and non-hibernating Richardson's ground squirrel (Spermophilus richardsonii) and its inability to bind to brain fatty acid binding protein

被引：10
作者：
Stewart, JM
Boudreau, NM
Blakely, JA
Storey, KB
机构：
[1] Mt Allison Univ, Dept Biol, Biochem Programme, Sackville, NB E4L 1G7, Canada
[2] Carleton Univ, Inst Biochem, Dept Biol, Ottawa, ON K1S 5B6, Canada
来源：
JOURNAL OF THERMAL BIOLOGY | 2002年 / 27卷 / 04期
基金：
加拿大自然科学与工程研究理事会;
关键词：
oleamide; hibernation; sleep deprivation; brain fatty acid-binding protein; Richardson's ground squirrel;
D O I：
10.1016/S0306-4565(01)00093-6
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Hibernation has been suggested to cause sleep debt, and since oleamide is elevated in the central nervous system of sleep-deprived mammals we hypothesized that brains from hibernating mammals would contain more oleamide than those that were not hibernating. Oleamide was 2.6-fold greater in brains of hibernating Richardson's ground squirrel (Spermophilus richardsonii) than in euthermic brains. Additionally. brain fatty acid-binding protein did not bind oleamide and does not represent a solubilized pool of oleamide. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：309 / 315
页数：7
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