An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer

被引：47

作者：

Wei, Jingsun ^{[1
]}

Ge, Xiaoxu ^{[1
]}

Tang, Yang ^{[1
]}

Qian, Yucheng ^{[1
]}

Lu, Wei ^{[1
]}

Jiang, Kai ^{[1
]}

Fang, Yimin ^{[1
]}

Hwang, Maxwell ^{[1
]}

Fu, Dongliang ^{[1
]}

Xiao, Qian ^{[1
]}

Ding, Kefeng ^{[1
]}

机构：

[1] Zhejiang Univ Sch Med, Affiliated Hosp 2, Dept Colorectal Surg & Oncol, Key Lab Canc Prevent & Intervent,Minist Educ, Hangzhou, Zhejiang, Peoples R China

来源：

JOURNAL OF ONCOLOGY | 2020年 / 2020卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

CELL APOPTOSIS; INHIBITION; STATISTICS; EXPRESSION; PATHWAY; DEATH;

D O I：

10.1155/2020/4728947

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose. Colorectal cancer is one of the most common malignant primary tumors, prone to metastasis, and associated with a poor prognosis. As autophagy is closely related to the development and treatment of colorectal cancer, we investigated the potential prognostic value of long noncoding RNA (lncRNA) associated with autophagy in colorectal cancer. Methods. In this study, we acquired information on the expression of lncRNAs in colorectal cancer from the Cancer Genome Atlas (TCGA) database and found that 860 lncRNAs were associated with autophagy-related genes. Subsequently, univariate Cox regression analysis was used to investigate 32 autophagy-related lncRNAs linked to colon cancer prognosis. Subsequently, eight of the 32 autophagy-related lncRNAs (i.e., long intergenic nonprotein coding RNA 1503 [LINC01503], ZEB1 antisense RNA 1 [ZEB1-AS1], AC087481.3, AC008760.1, AC073896.3, AL138756.1, AL022323.1, and TNFRSF10A-AS1) were selected through multivariate Cox regression analysis. Based on these autophagy-related lncRNAs, a risk signature was constructed, and the patients were divided into highand low-risk groups. Results. The high-risk group's overall survival time was significantly shorter than that of the low-risk group (p < 0.0001). Receiver operating characteristic curve analysis was performed to further confirm the validity of the model (area under the curve: 0.689). Moreover, multivariate regression suggested that the risk score was a significant prognostic risk factor in colorectal cancer. Gene set enrichment analysis showed that these gene sets are significantly enriched in cancer-related pathways, such as Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling. Conclusion. (e risk signature of eight autophagy-related lncRNAs has prognostic potential for colorectal cancer. These autophagy-related lncRNAs may play a vital role in the biology of colorectal cancer.

引用

页数：13

共 49 条

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