miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells

被引：82
作者：
Liu, Jingjing [1 ]
Wang, Xu [2 ]
Yang, Xiaoning [1 ]
Liu, Yunpeng [2 ]
Shi, Ying [2 ]
Ren, Jianlin [1 ,2 ]
Guleng, Bayasi [1 ,2 ]
机构：
[1] Xiamen Univ, Zhongshan Hosp, Dept Gastroenterol, Xiamen 361004, Fujian Province, Peoples R China
[2] Xiamen Univ, Coll Med, Fac Clin Med, Xiamen 361005, Fujian Province, Peoples R China
来源：
CANCER LETTERS | 2014年 / 347卷 / 01期
基金：
中国国家自然科学基金;
关键词：
miR-423-5p; Trefoil factor 1 (TFF1); Expression regulation; Gastric cancer; Proliferation and invasion; GROWTH-FACTOR; PS2; GENE; PEPTIDES; EXPRESSION; MICRORNAS; TFF1; MIGRATION; REGION; DIFFERENTIATION; INDUCTION;
D O I：
10.1016/j.canlet.2014.01.024
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
TFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：98 / 104
页数：7
相关论文
共 34 条
[1]   Transcription factor GATA-6 activates expression of gastroprotective trefoil genes TFF1 and TFF2 [J].
Al-azzeh, ED ;
Fegert, P ;
Blin, N ;
Gött, P .
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2000, 1490 (03) :324-332
[2]   MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].
Asangani, I. A. ;
Rasheed, S. A. K. ;
Nikolova, D. A. ;
Leupold, J. H. ;
Colburn, N. H. ;
Post, S. ;
Allgayer, H. .
ONCOGENE, 2008, 27 (15) :2128-2136
[3]   microRNA-451 Regulates Macrophage Migration Inhibitory Factor Production and Proliferation of Gastrointestinal Cancer Cells [J].
Bandres, Eva ;
Bitarte, Nerea ;
Arias, Fernando ;
Agorreta, Jackeline ;
Fortes, Puri ;
Agirre, Xabi ;
Zarate, Ruth ;
Diaz-Gonzalez, Juan A. ;
Ramirez, Natalia ;
Sola, Jesus J. ;
Jimenez, Paula ;
Rodriguez, Javier ;
Garcia-Foncillas, Jesus .
CLINICAL CANCER RESEARCH, 2009, 15 (07) :2281-2290
[4]   Hepatocyte nuclear factor 3 (winged helix domain) activates trefoil factor gene TFF1 through a binding motif adjacent to the TATAA box [J].
Beck, S ;
Sommer, P ;
Silva, ED ;
Blin, N ;
Gött, P .
DNA AND CELL BIOLOGY, 1999, 18 (02) :157-164
[5]   The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis [J].
Bossenmeyer-Pourié, C ;
Kannan, R ;
Ribieras, S ;
Wendling, C ;
Stoll, I ;
Thim, L ;
Tomasetto, C ;
Rio, MC .
JOURNAL OF CELL BIOLOGY, 2002, 157 (05) :761-770
[6]   Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs [J].
Cai, XZ ;
Hagedorn, CH ;
Cullen, BR .
RNA, 2004, 10 (12) :1957-1966
[7]  
Calnan DP, 1999, J PATHOL, V188, P312, DOI 10.1002/(SICI)1096-9896(199907)188:3<312::AID-PATH360>3.0.CO
[8]  
2-P
[9]   Causes and consequences of microRNA dysregulation in cancer [J].
Croce, Carlo M. .
NATURE REVIEWS GENETICS, 2009, 10 (10) :704-714
[10]   TREFOIL PEPTIDES PROMOTE EPITHELIAL MIGRATION THROUGH A TRANSFORMING GROWTH-FACTOR BETA-INDEPENDENT PATHWAY [J].
DIGNASS, A ;
LYNCHDEVANEY, K ;
KINDON, H ;
THIM, L ;
PODOLSKY, DK .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (01) :376-383
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