Site-specific hydroxyalkylation of chromones via alcohol mediated Minisci-type radical conjugate addition

被引：21

作者：

Chen, Rongzhen ^{[1
]}

Yu, Jin-Tao ^{[1
]}

Cheng, Jiang ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Jiangsu Prov Key Lab Fine Petrochem Engn, Changzhou 213164, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 11期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; BOND FUNCTIONALIZATION; OXIDATIVE FUNCTIONALIZATION; ENANTIOSELECTIVE FORMATION; GRIGNARD-REAGENTS; COUPLING REACTION; CARBON; METHANOL; ETHERS; FLAVONES;

D O I：

10.1039/c8ob00392k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free site-specific C2-hydroxyalkylation of chromones through the Minisci-type reaction using simple alcohols was developed. This transformation proceeds via radical sp(3) C-H activation and subsequent conjugate addition, generating a series of C2-hydroxyalkylated chromanones in moderate to good yields. Besides, ethers were also compatible in this Minisci reaction, leading to corresponding C2 ether-substituted chromanones.

引用

页码：1823 / 1827

页数：5

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