Novel predictive risk factor for Erectile Dysfunction: Serum folic acid

被引:5
作者
Gupta, Abhimanyu [1 ]
Priyadarshi, Shivam [1 ]
Vyas, Nachiket [1 ]
Sharma, Govind [1 ]
Swain, Prafulla Kumar [2 ]
机构
[1] SMS Med Coll & Hosp, Dept Urol & Renal Transplant, Jaipur 302004, Rajasthan, India
[2] Utkal Univ, Dept Stat, Bhubaneswar, India
关键词
endothelial dysfunction; erectile dysfunction; folic acid deficiency; Indian population; HYPERHOMOCYSTEINEMIA; MEN; ASSOCIATION; DISEASE;
D O I
10.1111/and.13890
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
The purpose of this study was to compare the serum Folic Acid (FA) levels in patients with Erectile Dysfunction (ED) and healthy controls and whether levels vary with its severity. The study was carried out on 77 sexually active individuals, out of which 41 complained of ED and 36 were apparently normal. Patients were excluded if they had any diseases known to cause ED. The severity was further categorised based on IIEF-5 scores. Blood serum levels of testosterone, lipid profile, random blood sugar, liver function test, renal function test and FA levels were obtained in each patient. Independent-samples t test of significance was used when comparing between two means. Pearson's correlation coefficient (r) test was used for correlating data. All clinical and biochemical parameters except FA were comparable in both the groups. FA levels were significantly decreased in ED group (5.29 vs. 10.8; p value = .004). Smoking habits were comparable between the groups, and FA levels did not vary among smokers and nonsmokers (p value = .46). Serum FA levels significantly declined with increasing severity of ED (8.28 vs. 5.56 vs. 4.37 vs. 3.5; p value < .001). Thus, decreased FA might possibly be one of the novel risk factors for ED.
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页数:5
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共 28 条
[1]  
Agostini R, 2006, Eur Rev Med Pharmacol Sci, V10, P247
[2]   Low serum folic acid can be a potential independent risk factor for erectile dysfunction: a prospective case-control study [J].
Attia, Attia Abd Allah ;
Amer, Mohamed Abd El Mawgood ;
Hassan, Mamdouh ;
GamalEl Din, Sameh Fayek .
INTERNATIONAL UROLOGY AND NEPHROLOGY, 2019, 51 (02) :223-229
[3]   Endothelial dysfunction and erectile dysfunction in the aging man [J].
Aversa, Antonio ;
Bruzziches, Roberto ;
Francomano, Davide ;
Natali, Marco ;
Gareri, Pietro ;
Spera, Giovanni .
INTERNATIONAL JOURNAL OF UROLOGY, 2010, 17 (01) :38-47
[4]   Hyperhomocysteinemia and Endothelial Dysfunction [J].
Cheng, Zhong-Jian ;
Yang, Xiaofeng ;
Wang, Hong .
CURRENT HYPERTENSION REVIEWS, 2009, 5 (02) :158-165
[5]   The Endothelial-Erectile Dysfunction Connection: An Essential Update [J].
Costa, Carla ;
Virag, Ronald .
JOURNAL OF SEXUAL MEDICINE, 2009, 6 (09) :2390-2404
[6]   Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro [J].
Cui, Shanshan ;
Li, Wen ;
Lv, Xin ;
Wang, Pengyan ;
Gao, Yuxia ;
Huang, Guowei .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (05)
[7]   Hyperhomocysteinemia:: a novel risk factor for erectile dysfunction [J].
Demir, Tevfik ;
Comlekci, Abdurrahman ;
Demir, Omer ;
Gulcu, Aytac ;
Calypkan, Sezer ;
Argun, Leyla ;
Secil, Mustafa ;
Yepil, Sena ;
Esen, Adil .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2006, 55 (12) :1564-1568
[8]   Folic acid supplementation improves erectile function in patients with idiopathic vasculogenic erectile dysfunction by lowering peripheral and penile homocysteine plasma levels: a case-control study [J].
Elshahid, A. R. M. ;
Shahein, I. M. ;
Mohammed, Y. F. ;
Ismail, N. F. ;
Zakarria, H. B. Abd El-Razek ;
GamalEl Din, S. F. .
ANDROLOGY, 2020, 8 (01) :148-153
[9]   A Systematic Review of the Association Between Erectile Dysfunction and Cardiovascular Disease [J].
Gandaglia, Giorgio ;
Briganti, Alberto ;
Jackson, Graham ;
Kloner, Robert A. ;
Montorsi, Francesco ;
Montorsi, Piero ;
Vlachopoulos, Charalambos .
EUROPEAN UROLOGY, 2014, 65 (05) :968-978
[10]   Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease [J].
Gazzaruso, Carmine ;
Solerte, Sebastiano B. ;
Pujia, Arturo ;
Coppola, Adriana ;
Vezzoli, Monia ;
Salvucci, Fabrizio ;
Valenti, Cinzia ;
Giustina, Andrea ;
Garzaniti, Adriana .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (21) :2040-2044