Pharmacokinetics and acetylcholine releasing effects of ginsenoside Rg1 in hippocampus of beta-amyloid model rats

被引：10

作者：

Liu, Yang ^{[1
]}

Gao, Yan ^{[2
]}

Li, Ke-Xin ^{[2
]}

Xue, Wei ^{[2
]}

机构：

[1] Peking Univ, Dept Pharm, Peoples Hosp, Beijing 100730, Peoples R China

[2] Beijing Hosp, Dept Clin Pharmacol, Beijing Key Lab Drug Clin Risk & Personalized Med, Beijing 100044, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2019年 / 21卷 / 08期

关键词：

Ginsenoside Rg1; pharmacokinetics; acetylcholine; hippocampus; ALZHEIMERS-DISEASE; TISSUE DISTRIBUTION; CHOLINERGIC SYSTEM; OLIGOMERS; BRAIN; METABOLISM; EXCRETION; ADDLS;

D O I：

10.1080/10286020.2018.1540596

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This study aimed at investigating the pharmacokinetics (PK) and acetylcholine (Ach) releasing effects of ginsenoside Rg1 in hippocampus (HIP) of soluble oligomeric assemblies of amyloid beta (ADDLs) induced Alzheimer's disease (AD) model rats. Extracellular fluid was collected by microdialysis technique. The concentrations of Rg1 and Ach in dialysates were detected by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. The results showed, after administration, Rg1 was soon detected in the HIP of model rats and extracellular Ach concentrations in the HIP were significantly increased. [GRAPHICS] .

引用

页码：772 / 781

页数：10

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