Telomerase regulation at the telomere: A binary switch

被引：11
作者：
Loayza, D [1 ]
de Lange, T [1 ]
机构：
[1] Rockefeller Univ, Cell Biol & Genet Lab, New York, NY 10021 USA
来源：
CELL | 2004年 / 117卷 / 03期
关键词：
D O I：
10.1016/S0092-8674(04)00409-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Telomerase is known to preferentially elongate the shortest telomeres in a cell. Using an elegant yeast assay, Texeira et al. (2004 [this issue of Cell]) address what aspect of telomerase action is regulated by telomere length: the frequency or the extent of telomere elongation. They show that short telomeres are elongated more frequently than long telomeres, arguing that telomeres switch between two states, one that allows telomere extension and one that does not.
引用
收藏
页码：279 / 280
页数：2
相关论文
共 7 条
[1]   A RAP1-INTERACTING PROTEIN INVOLVED IN TRANSCRIPTIONAL SILENCING AND TELOMERE LENGTH REGULATION [J].
HARDY, CFJ ;
SUSSEL, L ;
SHORE, D .
GENES & DEVELOPMENT, 1992, 6 (05) :801-814
[2]   The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability [J].
Hemann, MT ;
Strong, MA ;
Hao, LY ;
Greider, CW .
CELL, 2001, 107 (01) :67-77
[3]   POT1 as a terminal transducer of TRF1 telomere length control [J].
Loayza, D ;
de Lange, T .
NATURE, 2003, 423 (6943) :1013-1018
[4]   A protein-counting mechanism for telomere length regulation in yeast [J].
Marcand, S ;
Gilson, E ;
Shore, D .
SCIENCE, 1997, 275 (5302) :986-990
[5]   Regulation of telomerase by telomeric proteins [J].
Smogorzewska, A ;
de Lange, T .
ANNUAL REVIEW OF BIOCHEMISTRY, 2004, 73 :177-208
[6]   Telomere length homeostasis is achieved via a switch between telomerase-extendible and -nonextendible states [J].
Teixeira, MT ;
Arneric, M ;
Sperisen, P ;
Lingner, J .
CELL, 2004, 117 (03) :323-335
[7]   Novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae [J].
Wotton, D ;
Shore, D .
GENES & DEVELOPMENT, 1997, 11 (06) :748-760
1