Emerging evidence for functional peptides encoded by short open reading frames

被引:429
作者
Andrews, Shea J. [1 ]
Rothnagel, Joseph A. [1 ]
机构
[1] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia
基金
英国医学研究理事会;
关键词
LONG NONCODING RNAS; MESSENGER-RNA; TRANSLATIONAL REGULATION; 5'-UNTRANSLATED REGIONS; GENE STRUCTURE; TRANSCRIPTIONAL ACTIVITY; PROVIDES EVIDENCE; SMALL PROTEINS; HUMAN GENOME; IDENTIFICATION;
D O I
10.1038/nrg3520
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Short open reading frames (sORFs) are a common feature of all genomes, but their coding potential has mostly been disregarded, partly because of the difficulty in determining whether these sequences are translated. Recent innovations in computing, proteomics and high-throughput analyses of translation start sites have begun to address this challenge and have identified hundreds of putative coding sORFs. The translation of some of these has been confirmed, although the contribution of their peptide products to cellular functions remains largely unknown. This Review examines this hitherto overlooked component of the proteome and considers potential roles for sORF-encoded peptides.
引用
收藏
页码:193 / 204
页数:12
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