Interpretation of C-Reactive Protein Concentrations in Critically Ill Patients

被引：109

作者：

Lelubre, Christophe ^{[1
,2
]}

Anselin, Sophie ^{[1
]}

Boudjeltia, Karim Zouaoui ^{[2
]}

Biston, Patrick ^{[1
]}

Piagnerelli, Michael ^{[1
,2
]}

机构：

[1] Univ Libre Bruxelles, CHU Charleroi, Dept Intens Care, B-6000 Charleroi, Belgium

[2] CHU Charleroi, Expt Med Lab, ULB Unit 222, B-6110 Montignies le Tilleul, Belgium

来源：

BIOMED RESEARCH INTERNATIONAL | 2013年 / 2013卷

关键词：

COMMUNITY-ACQUIRED PNEUMONIA; INTENSIVE-CARE UNITS; OXIDE SYNTHASE EXPRESSION; ANTIMICROBIAL THERAPY; ENDOTHELIAL FUNCTION; PROMOTES APOPTOSIS; ANTIBIOTIC-THERAPY; SEVERE SEPSIS; SERUM-LEVELS; SOFA SCORE;

D O I：

10.1155/2013/124021

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Infection is often difficult to recognize in critically ill patients because of the marked coexisting inflammatory process. Lack of early recognition prevents timely resuscitation and effective antimicrobial therapy, resulting in increased morbidity and mortality. Measurement of a biomarker, such as C-reactive protein (CRP) concentration, in addition to history and physical signs, could facilitate diagnosis. Although frequently measured in clinical practice, few studies have reported on the pathophysiological role of this biomarker and its predictive value in critically ill patients. In this review, we discuss the pathophysiological role of CRP and its potential interpretation in the inflammatory processes observed in critically ill patients.

引用

页数：11

共 73 条

[1] Topology and structure of the C1q-binding site on C-reactive protein [J].

Agrawal, A ;

Shrive, AK ;

Greenhough, TJ ;

Volanakis, JE .

JOURNAL OF IMMUNOLOGY, 2001, 166 (06) :3998-4004

[2] Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care [J].

Angus, DC ;

Linde-Zwirble, WT ;

Lidicker, J ;

Clermont, G ;

Carcillo, J ;

Pinsky, MR .

CRITICAL CARE MEDICINE, 2001, 29 (07) :1303-1310

[3] Plasma C-Reactive Protein Levels Are Associated With Improved Outcome in ARDS [J].

Bajwa, Ednan K. ;

Khan, Uzma A. ;

Januzzi, James L. ;

Gong, Michelle N. ;

Thompson, Taylor ;

Christiani, David C. .

CHEST, 2009, 136 (02) :471-480

[4] Effects of CRP infusion on endothelial function and coagulation in normocholesterolemic and hypercholesterolemic subjects [J].

Bisoendial, Radjesh J. ;

Kastelein, John J. P. ;

Peters, Stephan L. M. ;

Levels, Johannes H. M. ;

Birjmohun, Rakesh ;

Rotmans, Joris I. ;

Hartman, Daniel ;

Meijers, Joost C. M. ;

Levi, Marcel ;

Stroes, Erik S. G. .

JOURNAL OF LIPID RESEARCH, 2007, 48 (04) :952-960

[5] Activation of inflammation and coagulation after infusion of C-reactive protein in humans [J].

Bisoendial, RJ ;

Kastelein, JJP ;

Levels, JHM ;

Zwaginga, JJ ;

van den Bogaard, B ;

Reitsma, PH ;

Meijers, JCM ;

Hartman, D ;

Levi, M ;

Stroes, ESG .

CIRCULATION RESEARCH, 2005, 96 (07) :714-716

[6] Serum levels of C-reactive protein and procalcitonin in critically ill patients with cirrhosis of the liver [J].

Bota, DP ;

Van Nuffelen, M ;

Zakariah, AN ;

Vincent, JL .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2005, 146 (06) :347-351

[7] Usefulness of consecutive C-reactive protein measurements in follow-up of severe community-acquired pneumonia [J].

Bruns, A. H. W. ;

Oosterheert, J. J. ;

Hak, E. ;

Hoepelman, A. I. M. .

EUROPEAN RESPIRATORY JOURNAL, 2008, 32 (03) :726-732

[8] Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: Linking obesity to vascular inflammation [J].

Calabro, P ;

Chang, DW ;

Willerson, JT ;

Yeh, ETH .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 46 (06) :1112-1113

[9]

Castelli GP, 2006, MINERVA ANESTESIOL, V72, P69

[10] C-reactive protein down-regulates endothelial nitric oxide synthase expression and promotes apoptosis in endothelial progenitor cells through receptor for advanced glycation end-products [J].

Chen, Jianfei ;

Jin, Jun ;

Song, Minbao ;

Dong, Hongmei ;

Zhao, Can ;

Huang, Lan .

GENE, 2012, 496 (02) :128-135

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