Dynamic particle ordering in oscillatory inertial microfluidics

被引:30
作者
Dietsche, Claudius [1 ,2 ]
Mutlu, Baris R. [1 ]
Edd, Jon F. [1 ,3 ]
Koumoutsakos, Petros [2 ]
Toner, Mehmet [1 ,4 ]
机构
[1] Harvard Med Sch, Massachusetts Gen Hosp, Ctr Engn Med & Surg Serv, BioMEMS Resource Ctr, Boston, MA 02114 USA
[2] Swiss Fed Inst Technol, Computat Sci & Engn Lab, Clausiusstr 33, CH-8092 Zurich, Switzerland
[3] Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
[4] Shriners Hosp Children, Boston, MA 02114 USA
关键词
Microfluidics; Oscillatory flow; Inertial focusing; Train of particles; Hydrodynamic self-assembly; SEPARATION; FLOW; CELLS;
D O I
10.1007/s10404-019-2242-x
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Particles suspended in conduit flows at small and intermediate Reynolds numbers cluster on specific focal positions while also forming particle pairs and trains due to flow-mediated interactions. The recent introduction of oscillatory inertial microfluidics has enabled the creation of virtually infinite channels, allowing the manipulation of particles at extremely low particle Reynolds numbers (Re-p<<1). Here, we investigate experimentally the dynamics of formation, the robustness and the stability of particle pairs, and the precision of the inter-particle distance in an oscillatory flow field, in microchannels with a rectangular cross section. Our results indicate that the cross-sectional arrangement of the particles is fundamental in determining the characteristics of the resulting particle pair.
引用
收藏
页数:8
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