Vigilance for veterinary medicinal products: Reports of adverse reactions in the year 2014

被引:1
作者
Muentener, C. R. [1 ,2 ]
Kupper, J. [3 ]
Naegeli, H. [1 ]
Schaeublin, M. [2 ]
机构
[1] Univ Zurich, Inst Vet Pharmakol & Toxikol, CH-8006 Zurich, Switzerland
[2] Schweizer Heilmittelinst, Swissmed, Bern, Switzerland
[3] Tox Info Suisse, Zurich, Switzerland
来源
SCHWEIZER ARCHIV FUR TIERHEILKUNDE | 2015年 / 157卷 / 11期
关键词
Pharmacovigilance; vaccinovigilance; antiparasitic products; COX-2; inhibitors; buprenorphine; CYCLOOXYGENASE-2; INHIBITOR; COX-2; SYNTHASE; NSAIDS; DRUGS; SAFE; DOGS;
D O I
10.17236/sat00039
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
During the year 2014, a total of 268 adverse reactions due to Swissmedic-authorized veterinary medicinal products were reported representing an increase of 7% compared to the previous year. Similar to previous years, most of the reactions reported were linked to the use of antiparasitic products (47.8%) or antiinfectives (9.3%). In 10.80% of the reports, reactions were described after the use of products acting on the hormonal system. The affected animal species were primarily dogs (182 reports), cats (58 reports), and cattle (16 reports). Additionally, 33 reports were provided within the frame of consultations with the toxicological information centre in Zurich (Tox Info Suisse). We present a short overview of the safety of COX-2 inhibitors and a series of reactions following the use of a parenteral buprenorphine solution. Finally, the vaccinovigilance program received 124 declarations following the application of various vaccines, but no detailed analysis of those reports is available.
引用
收藏
页码:601 / 605
页数:5
相关论文
共 16 条
[1]   Chronic gastric ulcer healing in rats subjected to selective and non-selective cyclooxygenase-2 inhibitors [J].
Berenguer, B ;
de la Lastra, CA ;
Moreno, FJ ;
Martín, MJ .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 442 (1-2) :125-135
[2]  
Bombardier C, 2002, AM J CARDIOL, V89, p3D
[3]  
Demuth D., 2015, TIERARZNEIMITTELKOMP
[4]  
Fichtl B., 2009, ALLGEMEINE SPEZIELLE, P64
[5]   COX-2 and beyond: Approaches to prostaglandin inhibition in human disease [J].
FitzGerald, G .
NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (11) :879-890
[6]  
FU JY, 1990, J BIOL CHEM, V265, P16737
[7]   Selective cyclo-oxygenase-2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach [J].
Gretzer, B ;
Ehrlich, K ;
Maricic, N ;
Lambrecht, N ;
Respondek, M ;
Peskar, BM .
BRITISH JOURNAL OF PHARMACOLOGY, 1998, 123 (05) :927-935
[8]   COX-2 selective nonsteroidal anti-inflammatory drugs - Do they really offer any advantages? [J].
Jackson, LM ;
Hawkey, CJ .
DRUGS, 2000, 59 (06) :1207-1216
[9]  
Lascelles BDX, 2005, VET THER, V6, P237
[10]   Gastrointestinal tract perforation in dogs treated with a selective cyclooxygenase-2 inhibitor: 29 cases (2002-2003) [J].
Lascelles, BDX ;
Blikslager, AT ;
Fox, SM ;
Reece, D .
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2005, 227 (07) :1112-1117