The VISYT trial: Venom Immunotherapy Safety and Tolerability with purified vs nonpurified extracts

被引:33
作者
Bilo, M. Beatrice [2 ]
Severino, Maurizio [3 ]
Cilia, Marcello [4 ]
Pio, Antonio [5 ]
Casino, Giuseppe [6 ]
Ferrarini, Ettore [7 ]
Campodonico, Patrizia [1 ]
Milani, Massimo [1 ]
机构
[1] ALK Abello Italy, Dept Med, I-20020 Lainate, Italy
[2] Osped Riuniti Ancona, Allergy Clin, Ancona, Italy
[3] Osped San Giovanni Dio, Allergy Clin, Florence, Italy
[4] Osped Civile Locri, Allergy Clin, Locri, Italy
[5] PO Curteri Hosp, Allergy Clin, Salerno, Italy
[6] Presidio Osped Pie Monte Matese ASL Caserta 1, Allergy & Resp Operat Unit, Caserta, Italy
[7] Osped Umberto 1 Siracusa, Allergy Clin, Siracusa, Italy
关键词
HYMENOPTERA VENOM; ALUMINUM-HYDROXIDE; CLINICAL-PRACTICE; HONEYBEE VENOM; ALLERGY;
D O I
10.1016/S1081-1206(10)60144-5
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Venom immunotherapy (VIT) is a highly effective treatment but can induce systemic adverse effects. Objective: To evaluate the safety and tolerability of VIT with purified and nonpurified extracts for treating yellow jacket and honeybee allergy. Methods: Ninety-four patients (mean age, 46 years) with a history of insect venom allergy were randomly allocated to undergo purified extract VIT (group A [44 patients]) or nonpurified extract VIT (group B [50 patients]). Fifty-six patients were allergic to yellow jacket venom (group A: 25; group B: 3 1) and 38 to honeybee (19 per group). The induction phase was performed using a 2- or 7-day ultrarush scheme. The maintenance phase lasted 11 weeks. Local and systemic reactions were recorded after each injection. Results: A total of 1,401 VIT injections were performed. Six systemic reactions were observed in 4 patients (honeybee-allergic patients only) (4% of patients; 0.4% of injections): 1 patient in group A (2%) and in 3 in group B (6%) (P = .57). Local extensive reactions were recorded after 5 injections in 4 patients (9%) in group A (2 yellow jacket- and 2 honeybee-allergic patients) and after 17 injections in 12 patients (24%) in group B (8 yellow jacket- and 4 honeybee-allergic patients) (P = .02). Total reactions (systemic and large local) numbered 6 in group A (0.9% of injections; 11% of patients) and 20 in group B (2.7% of injections; 30% of patients) (P = .001). Conclusion: In patients with honeybee or yellow jacket venom allergy, VIT with purified extracts has a significantly lower propensity toward severe local reactions compared with VIT with nonpurified extracts. Ann Allergy Asthma Immunol. 2009; 103:57-61.
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收藏
页码:57 / 61
页数:5
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